speC:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

SpeC

Synonyms

ornithine decarboxylase, constitutive[1], B2965[2][1], SpeC[2][1] , ECK2960, JW5482, b2965

Product description

SpeC[2][3];

Component of ornithine decarboxylase, biosynthetic[2][3]

Ornithine decarboxylase[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003824

catalytic activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000310

F

Seeded from EcoCyc (v14.0)

complete

GO:0003824

catalytic activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008286

F

Seeded from EcoCyc (v14.0)

complete

GO:0003824

catalytic activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015421

F

Seeded from EcoCyc (v14.0)

complete

GO:0003824

catalytic activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015422

F

Seeded from EcoCyc (v14.0)

complete

GO:0004586

ornithine decarboxylase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:4.1.1.17

F

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011193

C

Seeded from EcoCyc (v14.0)

complete

GO:0006520

cellular amino acid metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011193

P

Seeded from EcoCyc (v14.0)

complete

GO:0008295

spermidine biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0745

P

Seeded from EcoCyc (v14.0)

complete

GO:0016829

lyase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0456

F

Seeded from EcoCyc (v14.0)

complete

GO:0016831

carboxy-lyase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005308

F

Seeded from EcoCyc (v14.0)

complete

GO:0016831

carboxy-lyase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011193

F

Seeded from EcoCyc (v14.0)

complete

GO:0016831

carboxy-lyase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0210

F

Seeded from EcoCyc (v14.0)

complete

GO:0030170

pyridoxal phosphate binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015421

F

Seeded from EcoCyc (v14.0)

complete

GO:0030170

pyridoxal phosphate binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015422

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of ornithine decarboxylase, biosynthetic

could be indirect

Protein

dapD

PMID:19402753[5]

LCMS(ID Probability):99.6

Protein

hpt

PMID:19402753[5]

LCMS(ID Probability):99.6

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MGQGFPPCPV FLLPRNGFAL MKSMNIAASS ELVSRLSSHR RVVALGDTDF TDVAAVVITA
ADSRSGILAL LKRTGFHLPV FLYSEHAVEL PAGVTAVING NEQQWLELES AACQYEENLL
PPFYDTLTQY VEMGNSTFAC PGHQHGAFFK KHPAGRHFYD FFGENVFRAD MCNADVKLGD
LLIHEGSAKD AQKFAAKVFH ADKTYFVLNG TSAANKVVTN ALLTRGDLVL FDRNNHKSNH
HGALIQAGAT PVYLEASRNP FGFIGGIDAH CFNEEYLRQQ IRDVAPEKAD LPRPYRLAII
QLGTYDGTVY NARQVIDTVG HLCDYILFDS AWVGYEQFIP MMADSSPLLL ELNENDPGIF
VTQSVHKQQA GFSQTSQIHK KDNHIRGQAR FCPHKRLNNA FMLHASTSPF YPLFAALDVN
AKIHEGESGR RLWAECVEIG IEARKAILAR CKLFRPFIPP VVDGKLWQDY PTSVLASDRR
FFSFEPGAKW HGFEGYAADQ YFVDPCKLLL TTPGIDAETG EYSDFGVPAT ILAHYLRENG
IVPEKCDLNS ILFLLTPAES HEKLAQLVAM LAQFEQHIED DSPLVEVLPS VYNKYPVRYR
DYTLRQLCQE MHDLYVSFDV KDLQKAMFRQ QSFPSVVMNP QDAHSAYIRG DVELVRIRDA
EGRIAAEGAL PYPPGVLCVV PGEVWGGAVQ RYFLALEEGV NLLPGFSPEL QGVYSETDAD
GVKRLYGYVL K
Length

731

Mol. Wt

81.56 kDa

pI

6.1 (calculated)

Extinction coefficient

77,700 - 79,325 (calc based on 30 Y, 6 W, and 13 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

101..543

PF01276 Orn/Lys/Arg decarboxylase, major domain

PMID:19920124[6]

Domain

568..701

PF03711 Orn/Lys/Arg decarboxylase, C-terminal domain

PMID:19920124[6]

Domain

4..95

PF03709 Orn/Lys/Arg decarboxylase, N-terminal domain

PMID:19920124[6]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=speC taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:90111522

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947457

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0009730

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P21169

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10961

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10961

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947457

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000950

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0954

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  6. ↑ 6.0 6.1 6.2 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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