sixA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

SixA

Synonyms

phosphohistidine phosphatase[1], B2340[2][1], YfcW[2][1], SixA[2][1] , ECK2334, JW2337, yfcW, b2340

Product description

G7211[2][3]

Phosphohistidine phosphatase affecting ArcB H-D phosphorelay; targets Hpt domain[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005737

cytoplasm

C

Seeded from Riley et al 2006 [1].

Missing: evidence, reference

GO:0004721

phosphoprotein phosphatase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0904

F

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

PMID:17628145[5]

IDA: Inferred from Direct Assay

C

complete

GO:0101006

protein histidine phosphatase activity

PMID:17628145[5]

IDA: Inferred from Direct Assay

F

complete

GO:0006464

protein modification process

PMID:17628145[5]

IMP: Inferred from Mutant Phenotype

P

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

slyD

PMID:19402753[6]

LCMS(ID Probability):99.6

Protein

folM

PMID:19402753[6]

LCMS(ID Probability):99.6

Protein

yfcL

PMID:19402753[6]

LCMS(ID Probability):99.6

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MQVFIMRHGD AALDAASDSV RPLTTNGCDE SRLMANWLKG QKVEIERVLV SPFLRAEQTL
EEVGDCLNLP SSAEVLPELT PCGDVGLVSA YLQALTNEGV ASVLVISHLP LVGYLVAELC
PGETPPMFTT SAIASVTLDE SGNGTFNWQM SPCNLKMAKA I
Length

161

Mol. Wt

17.207 kDa

pI

4.3 (calculated)

Extinction coefficient

13,980 - 14,605 (calc based on 2 Y, 2 W, and 5 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

2..103

PF00300 Phosphoglycerate mutase family

PMID:19920124[7]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=sixA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16130273

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:946815

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0007720

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P76502

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G7211

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG14126

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:946815

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120003786

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB3878

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 Hakoshima, T & Ichihara, H (2007) Structure of SixA, a histidine protein phosphatase of the ArcB histidine-containing phosphotransfer domain in Escherichia coli. Meth. Enzymol. 422 288-304 PubMed
  6. ↑ 6.0 6.1 6.2 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  7. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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