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References Suggestions


Standard Name


Gene Synonym(s)

ECK0391, b0397, JW0387, rmuA[1], rmuA

Product Desc.

ATP-dependent dsDNA exonuclease[2][3];

Component of SbcCD ATP-dependent dsDNA exonuclease[3]

DNA hairpin dsDNA 3'-exonuclease SbcCD, Mn(2+), ATP-dependent; ATP-independent 5' ssDNA endonuclease; required for recombinational repair of dsDNA breaks; cosuppressor with sbcB of recB recC mutations; heterodimeric[4]

Product Synonyms(s)

exonuclease, dsDNA, ATP-dependent[1], B0397[2][1], SbcC[2][1] , ECK0391, JW0387, rmuA, b0397

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): sbcC[2]

Quick Links

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SbcCD can cleave dsDNA 5' ends sealed by a hairpin or by covalent linko a protein. SbcCD limits recombination between short inverted repeats, but is also reported to be required for palindrome-stimulated deletion. SbcCD protein forms a large 1.2 megadalton complex. Second amino acid was sequenced in protein as Gly, but in all DNA samples is a Lys codon. Coiled coil protein.[4]


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  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.