sad:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

Sad

Synonyms

predicted aldehyde dehydrogenase[1], B1525[2][1], YneI[2][1] , ECK1518, JW5247, yneI, b1525

Product description

G6811[2][3]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0009013

succinate-semialdehyde dehydrogenase (NAD(P)+) activity

PMID:17873044[4]

IDA: Inferred from Direct Assay

F

complete

GO:0009013

succinate-semialdehyde dehydrogenase (NAD(P)+) activity

PMID:7011797[5]

IDA: Inferred from Direct Assay

F

complete

GO:0004777

succinate-semialdehyde dehydrogenase activity

PMID:17873044[4]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0009450

gamma-aminobutyric acid catabolic process

PMID:17873044[4]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0006807

nitrogen compound metabolic process

PMID:17873044[4]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc (v14.0)

complete

GO:0009450

gamma-aminobutyric acid catabolic process

PMID:7011797[5]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015590

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016160

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016161

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016162

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

P

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

rlmI

PMID:19402753[6]

LCMS(ID Probability):99.6

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MTHKGDTPMT ITPATHAISI NPATGEQLSV LPWAGADDIE NALQLAAAGF RDWRETNIDY
RAEKLRDIGK ALRARSEEMA QMITREMGKP INQARAEVAK SANLCDWYAE HGPAMLKAEP
TLVENQQAVI EYRPLGTILA IMPWNFPLWQ VMRGAVPIIL AGNGYLLKHA PNVMGCAQLI
AQVFKDAGIP QGVYGWLNAD NDGVSQMIKD SRIAAVTVTG SVRAGAAIGA QAGAALKKCV
LELGGSDPFI VLNDADLELA VKAAVAGRYQ NTGQVCAAAK RFIIEEGIAS AFTERFVAAA
AALKMGDPRD EENALGPMAR FDLRDELHHQ VEKTLAQGAR LLLGGEKMAG AGNYYPPTVL
ANVTPEMTAF REEMFGPVAA ITIAKDAEHA LELANDSEFG LSATIFTTDE TQARQMAARL
ECGGVFINGY CASDARVAFG GVKKSGFGRE LSHFGLHEFC NIQTVWKDRI
Length

470

Mol. Wt

50.586 kDa

pI

5.6 (calculated)

Extinction coefficient

51,910 - 52,785 (calc based on 9 Y, 7 W, and 7 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

4..457

PF00171 Aldehyde dehydrogenase family

PMID:19920124[7]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=sad taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:90111288

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947440

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0005092

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P76149

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G6811

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG13817

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947440

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120003400

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB3578

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 4.2 4.3 Fuhrer, T et al. (2007) Computational prediction and experimental verification of the gene encoding the NAD+/NADP+-dependent succinate semialdehyde dehydrogenase in Escherichia coli. J. Bacteriol. 189 8073-8 PubMed
  5. ↑ 5.0 5.1 Donnelly, MI & Cooper, RA (1981) Succinic semialdehyde dehydrogenases of Escherichia coli: their role in the degradation of p-hydroxyphenylacetate and gamma-aminobutyrate. Eur. J. Biochem. 113 555-61 PubMed
  6. ↑ Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  7. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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