rlmL:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

RlmL

Synonyms

predicted methyltransferase[1], YcbY[2][1], B0948[2][1], RlmL[2][1] , ECK0939, JW0931, ycbY, b0948

Product description

23S rRNA m2G2445 methyltransferase[2][3]

23S rRNA mG2445 methyltransferase, SAM-dependent[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003676

nucleic acid binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002052

F

Seeded from EcoCyc (v14.0)

complete

GO:0003676

nucleic acid binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002296

F

Seeded from EcoCyc (v14.0)

complete

GO:0003723

RNA binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0694

F

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01858

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017244

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

PMID:17010378[5]

IC: Inferred by Curator

GO:0008990

C

Seeded from EcoCyc (v14.0)

complete

GO:0008990

rRNA (guanine-N2-)-methyltransferase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01858

F

Seeded from EcoCyc (v14.0)

complete

GO:0008990

rRNA (guanine-N2-)-methyltransferase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017244

F

Seeded from EcoCyc (v14.0)

complete

GO:0008990

rRNA (guanine-N2-)-methyltransferase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.1.1.52

F

Seeded from EcoCyc (v14.0)

complete

GO:0031167

rRNA methylation

PMID:17010378[5]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc (v14.0)

complete

GO:0070475

rRNA base methylation

PMID:17010378[5]

IMP: Inferred from Mutant Phenotype

P

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

ynbC

PMID:15690043[6]

Experiment(s):EBI-886140

Protein

rplA

PMID:15690043[6]

Experiment(s):EBI-886140

Protein

yfiF

PMID:15690043[6]

Experiment(s):EBI-886140, EBI-879491

Protein

rplA

PMID:16606699[7]

Experiment(s):EBI-1138445

Protein

rpsC

PMID:16606699[7]

Experiment(s):EBI-1138445

Protein

ygfJ

PMID:16606699[7]

Experiment(s):EBI-1138445

Protein

nadE

PMID:16606699[7]

Experiment(s):EBI-1138445

Protein

napC

PMID:16606699[7]

Experiment(s):EBI-1138445

Protein

rplB

PMID:16606699[7]

Experiment(s):EBI-1138445

Protein

rpsI

PMID:16606699[7]

Experiment(s):EBI-1138445

Protein

fdnG

PMID:16606699[7]

Experiment(s):EBI-1138445

Protein

rpsG

PMID:16606699[7]

Experiment(s):EBI-1138445

Protein

rpsD

PMID:16606699[7]

Experiment(s):EBI-1138445

Protein

appY

PMID:16606699[7]

Experiment(s):EBI-1138445

Protein

rsuA

PMID:16606699[7]

Experiment(s):EBI-1138445

Protein

rplC

PMID:16606699[7]

Experiment(s):EBI-1138445

Protein

lsrK

PMID:16606699[7]

Experiment(s):EBI-1138445

Protein

yfgI

PMID:16606699[7]

Experiment(s):EBI-1138445

Protein

rplQ

PMID:16606699[7]

Experiment(s):EBI-1138445

Protein

rplA

PMID:19402753[8]

MALDI(Z-score):33.144073

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MNSLFASTAR GLEELLKTEL ENLGAVECQV VQGGVHFKGD TRLVYQSLMW SRLASRIMLP
LGECKVYSDL DLYLGVQAIN WTEMFNPGAT FAVHFSGLND TIRNSQYGAM KVKDAIVDAF
TRKNLPRPNV DRDAPDIRVN VWLHKETASI ALDLSGDGLH LRGYRDRAGI APIKETLAAA
IVMRSGWQPG TPLLDPMCGS GTLLIEAAML ATDRAPGLHR GRWGFSGWAQ HDEAIWQEVK
AEAQTRARKG LAEYSSHFYG SDSDARVIQR ARTNARLAGI GELITFEVKD VAQLTNPLPK
GPYGTVLSNP PYGERLDSEP ALIALHSLLG RIMKNQFGGW NLSLFSASPD LLSCLQLRAD
KQYKAKNGPL DCVQKNYHVA ESTPDSKPAM VAEDYTNRLR KNLKKFEKWA RQEGIECYRL
YDADLPEYNV AVDRYADWVV VQEYAPPKTI DAHKARQRLF DIIAATISVL GIAPNKLVLK
TRERQKGKNQ YQKLGEKGEF LEVTEYNAHL WVNLTDYLDT GLFLDHRIAR RMLGQMSKGK
DFLNLFSYTG SATVHAGLGG ARSTTTVDMS RTYLEWAERN LRLNGLTGRA HRLIQADCLA
WLREANEQFD LIFIDPPTFS NSKRMEDAFD VQRDHLALMK DLKRLLRAGG TIMFSNNKRG
FRMDLDGLAK LGLKAQEITQ KTLSQDFARN RQIHNCWLIT AA
Length

702

Mol. Wt

78.856 kDa

pI

9.1 (calculated)

Extinction coefficient

109,780 - 110,780 (calc based on 22 Y, 14 W, and 8 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

56..154

PF02926 THUMP domain

PMID:19920124[9]

Domain

162..376

PF01170 Putative RNA methylase family UPF0020

PMID:19920124[9]

Domain

427..669

PF10672 S-adenosylmethionine-dependent methyltransferase

PMID:19920124[9]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=rlmL taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128915

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945564

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0003211

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P75864

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G6488

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG13717

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945564

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120003088

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB3481

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 Lesnyak, DV et al. (2006) Identification of Escherichia coli m2G methyltransferases: I. the ycbY gene encodes a methyltransferase specific for G2445 of the 23 S rRNA. J. Mol. Biol. 364 20-5 PubMed
  6. ↑ 6.0 6.1 6.2 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  7. ↑ 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 7.12 7.13 7.14 7.15 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  8. ↑ Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  9. ↑ 9.0 9.1 9.2 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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