rihA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

RihA

Synonyms

ribonucleoside hydrolase 1[1], B0651[2][1], YbeK[2][1], RihA[2][1] , ECK0644, JW0646, ybeK, b0651

Product description

G6358[2][3]

Ribonucleoside hydrolase, pyrimidine specific[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0006206

pyrimidine base metabolic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01431

P

Seeded from EcoCyc (v14.0)

complete

GO:0009226

nucleotide-sugar biosynthetic process

P

Seeded from Riley et al 2006 [1].

Missing: evidence, reference

GO:0008152

metabolic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0326

P

Seeded from EcoCyc (v14.0)

complete

GO:0016787

hydrolase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0378

F

Seeded from EcoCyc (v14.0)

complete

GO:0016798

hydrolase activity, acting on glycosyl bonds

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01431

F

Seeded from EcoCyc (v14.0)

complete

GO:0016798

hydrolase activity, acting on glycosyl bonds

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0326

F

Seeded from EcoCyc (v14.0)

complete

GO:0005509

calcium ion binding

PMID:16411753[5]

IDA: Inferred from Direct Assay

F

complete

GO:0005515

protein binding

PMID:16411753[5]

IPI: Inferred from Physical Interaction

EcoliWiki:rihA


F

complete

GO:0046133

pyrimidine ribonucleoside catabolic process

PMID:11027694[6]

IMP: Inferred from Mutant Phenotype

P

A pyrimidine hydrolase, it catalyzes the hydrolysis of cytidine or uridine to cytosine or uracil and ribose.

complete

GO:0050263

ribosylpyrimidine nucleosidase activity

PMID:11027694[6]

IMP: Inferred from Mutant Phenotype

F

A pyrimidine hydrolase, it catalyzes the hydrolysis of cytidine or uridine to cytosine or uracil and ribose.

complete

GO:0045437

uridine nucleosidase activity

PMID:11027694[6]

IMP: Inferred from Mutant Phenotype

F

A pyrimidine hydrolase, it catalyzes the hydrolysis of cytidine or uridine to cytosine or uracil and ribose.

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

rhsC

PMID:16606699[7]

Experiment(s):EBI-1137587

Protein

gfcD

PMID:16606699[7]

Experiment(s):EBI-1137587

Protein

ydcS

PMID:16606699[7]

Experiment(s):EBI-1137587

Protein

rhsA

PMID:16606699[7]

Experiment(s):EBI-1137587

Protein

baeS

PMID:16606699[7]

Experiment(s):EBI-1137587

Protein

malT

PMID:16606699[7]

Experiment(s):EBI-1137587

Protein

arnA

PMID:16606699[7]

Experiment(s):EBI-1137587

Protein

paaA

PMID:16606699[7]

Experiment(s):EBI-1137587

Protein

nadE

PMID:16606699[7]

Experiment(s):EBI-1137587

Protein

btuD

PMID:16606699[7]

Experiment(s):EBI-1137587

Protein

mutS

PMID:16606699[7]

Experiment(s):EBI-1137587

Protein

hemB

PMID:16606699[7]

Experiment(s):EBI-1137587

Protein

emrA

PMID:16606699[7]

Experiment(s):EBI-1137587

Protein

baeR

PMID:16606699[7]

Experiment(s):EBI-1137587

Protein

nanE

PMID:16606699[7]

Experiment(s):EBI-1137587
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MALPILLDCD PGHDDAIAIV LALASPELDV KAITSSAGNQ TPEKTLRNVL RMLTLLNRTD
IPVAGGAVKP LMRELIIADN VHGESGLDGP ALPEPTFAPQ NCTAVELMAK TLRESAEPVT
IVSTGPQTNV ALLLNSHPEL HSKIARIVIM GGAMGLGNWT PAAEFNIYVD PEAAEIVFQS
GIPVVMAGLD VTHKAQIHVE DTERFRAIGN PVSTIVAELL DFFLEYHKDE KWGFVGAPLH
DPCTIAWLLK PELFTSVERW VGVETQGKYT QGMTVVDYYY LTGNKPNATV MVDVDRQGFV
DLLADRLKFY A
Length

311

Mol. Wt

33.822 kDa

pI

4.7 (calculated)

Extinction coefficient

32,430 - 32,805 (calc based on 7 Y, 4 W, and 3 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

2..311

PF01156 Inosine-uridine preferring nucleoside hydrolase

PMID:19920124[8]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=rihA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128634

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945503

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0002227

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P41409

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G6358

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG12701

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945503

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120002965

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB2563

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 Muzzolini, L et al. (2006) New insights into the mechanism of nucleoside hydrolases from the crystal structure of the Escherichia coli YbeK protein bound to the reaction product. Biochemistry 45 773-82 PubMed
  6. ↑ 6.0 6.1 6.2 Petersen, C & Møller, LB (2001) The RihA, RihB, and RihC ribonucleoside hydrolases of Escherichia coli. Substrate specificity, gene expression, and regulation. J. Biol. Chem. 276 884-94 PubMed
  7. ↑ 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 7.12 7.13 7.14 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  8. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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