prlC:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

PrlC

Synonyms

oligopeptidase A[1], B3498[2][1], OpdA[2][1], PrlC[2][1] , ECK3483, JW3465, opdA, b3498

Product description

oligopeptidase A[2][3]

Oligopeptidase A, zinc metalloprotease; involved in the degradation of cleaved signal peptides; suppressor allele of LamB signal sequence mutations; heat shock regulon; proteinase In, multifunctional protease[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004222

metalloendopeptidase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001567

F

Seeded from EcoCyc (v14.0)

complete

GO:0006508

proteolysis

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001567

P

Seeded from EcoCyc (v14.0)

complete

GO:0008233

peptidase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0645

F

Seeded from EcoCyc (v14.0)

complete

GO:0008237

metallopeptidase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0482

F

Seeded from EcoCyc (v14.0)

complete

GO:0008270

zinc ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0862

F

Seeded from EcoCyc (v14.0)

complete

GO:0016787

hydrolase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0378

F

Seeded from EcoCyc (v14.0)

complete

GO:0046872

metal ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

Seeded from EcoCyc (v14.0)

complete

GO:0006465

signal peptide processing

PMID:3053642[5]

IDA: Inferred from Direct Assay

P

complete

GO:0005737

cytoplasm

PMID:9792922[6]

TAS: Traceable Author Statement

C

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

yjhR

PMID:16606699[7]

Experiment(s):EBI-1146030

Protein

bcsZ

PMID:16606699[7]

Experiment(s):EBI-1146030
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

cytoplasm


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MTNPLLTPFE LPPFSKILPE HVVPAVTKAL NDCRENVERV VAQGAPYTWE NLCQPLAEVD
DVLGRIFSPV SHLNSVKNSP ELREAYEQTL PLLSEYSTWV GQHEGLYKAY RDLRDGDHYA
TLNTAQKKAV DNALRDFELS GIGLPKEKQQ RYGEIATRLS ELGNQYSNNV LDATMGWTKL
VTDEAELAGM PESALAAAKA QAEAKELEGY LLTLDIPSYL PVMTYCDNQA LREEMYRAYS
TRASDQGPNA GKWDNSKVME EILALRHELA QLLGFENYAF KSLATKMAEN PQQVLDFLTD
LAKRARPQGE KELAQLRAFA KAEFGVDELQ PWDIAYYSEK QKQHLYSISD EQLRPYFPEN
KAVNGLFEVV KRIYGITAKE RKDVDVWHPD VRFFELYDEN NELRGSFYLD LYARENKRGG
AWMDDCVGQM RKADGSLQKP VAYLTCNFNR PVNGKPALFT HDEVITLFHE FGHGLHHMLT
RIETAGVSGI SGVPWDAVEL PSQFMENWCW EPEALAFISG HYETGEPLPK ELLDKMLAAK
NYQAALFILR QLEFGLFDFR LHAEFRPDQG AKILETLAEI KKLVAVVPSP SWGRFPHAFS
HIFAGGYAAG YYSYLWADVL AADAFSRFEE EGIFNRETGQ SFLDNILSRG GSEEPMDLFK
RFRGREPQLD AMLEHYGIKG
Length

680

Mol. Wt

77.168 kDa

pI

5.1 (calculated)

Extinction coefficient

110,700 - 111,450 (calc based on 30 Y, 12 W, and 6 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

222..678

PF01432 Peptidase family M3

PMID:19920124[8]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=prlC taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16131370

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948016

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0011421

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P27298

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11441

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11441

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948016

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001405

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1411

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Novak, P & Dev, IK (1988) Degradation of a signal peptide by protease IV and oligopeptidase A. J. Bacteriol. 170 5067-75 PubMed
  6. ↑ Jiang, X et al. (1998) Escherichia coli prlC gene encodes a trypsin-like proteinase regulating the cell cycle. J. Biochem. 124 980-5 PubMed
  7. ↑ 7.0 7.1 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  8. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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