prfA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

PrfA

Synonyms

peptide chain release factor RF-1[1], B1211[2][1], Uar[2][1], SueB[2][1], PrfA[2][1] , ECK1199, JW1202, sueB, uar, b1211, ups?

Product description

peptide chain release factor RF1[2][3]

Peptide chain release factor 1, RF-1; translation termination factor recognizes UAG and UAA.[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003747

translation release factor activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000352

F

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00093

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004373

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005139

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0006412

translation

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0648

P

Seeded from EcoCyc (v14.0)

complete

GO:0006415

translational termination

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00093

P

Seeded from EcoCyc (v14.0)

complete

GO:0006415

translational termination

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000352

P

Seeded from EcoCyc (v14.0)

complete

GO:0006415

translational termination

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004373

P

Seeded from EcoCyc (v14.0)

complete

GO:0006415

translational termination

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005139

P

Seeded from EcoCyc (v14.0)

complete

GO:0016149

translation release factor activity, codon specific

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00093

F

Seeded from EcoCyc (v14.0)

complete

GO:0016149

translation release factor activity, codon specific

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004373

F

Seeded from EcoCyc (v14.0)

complete

GO:0016149

translation release factor activity, codon specific

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005139

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

nadE

PMID:16606699[5]

Experiment(s):EBI-1139187

Protein

groL

PMID:16606699[5]

Experiment(s):EBI-1139187

Protein

gabT

PMID:16606699[5]

Experiment(s):EBI-1139187

Protein

dnaK

PMID:16606699[5]

Experiment(s):EBI-1139187

Protein

rplD

PMID:16606699[5]

Experiment(s):EBI-1139187

Protein

waaU

PMID:15690043[6]

Experiment(s):EBI-889124

Protein

yghE

PMID:15690043[6]

Experiment(s):EBI-889124

Protein

yhgA

PMID:15690043[6]

Experiment(s):EBI-889124

Protein

ycjY

PMID:15690043[6]

Experiment(s):EBI-889124

Protein

basS

PMID:15690043[6]

Experiment(s):EBI-889124

Protein

frdC

PMID:15690043[6]

Experiment(s):EBI-889124

Protein

hyfR

PMID:15690043[6]

Experiment(s):EBI-889124

Protein

pheA

PMID:15690043[6]

Experiment(s):EBI-889124

Protein

leuS

PMID:19402753[7]

MALDI(Z-score):27.752698

Protein

ycjY

PMID:19402753[7]

LCMS(ID Probability):99.0

Protein

basS

PMID:19402753[7]

LCMS(ID Probability):99.0

Protein

hyfR

PMID:19402753[7]

LCMS(ID Probability):99.0

Protein

pheA

PMID:19402753[7]

LCMS(ID Probability):99.0

Protein

yhgA

PMID:19402753[7]

LCMS(ID Probability):99.0

Protein

frdC

PMID:19402753[7]

LCMS(ID Probability):99.0

Protein

waaU

PMID:19402753[7]

LCMS(ID Probability):99.0

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MKPSIVAKLE ALHERHEEVQ ALLGDAQTIA DQERFRALSR EYAQLSDVSR CFTDWQQVQE
DIETAQMMLD DPEMREMAQD ELREAKEKSE QLEQQLQVLL LPKDPDDERN AFLEVRAGTG
GDEAALFAGD LFRMYSRYAE ARRWRVEIMS ASEGEHGGYK EIIAKISGDG VYGRLKFESG
GHRVQRVPAT ESQGRIHTSA CTVAVMPELP DAELPDINPA DLRIDTFRSS GAGGQHVNTT
DSAIRITHLP TGIVVECQDE RSQHKNKAKA LSVLGARIHA AEMAKRQQAE ASTRRNLLGS
GDRSDRNRTY NFPQGRVTDH RINLTLYRLD EVMEGKLDML IEPIIQEHQA DQLAALSEQE
Length

360

Mol. Wt

40.517 kDa

pI

5.1 (calculated)

Extinction coefficient

21,430 - 21,805 (calc based on 7 Y, 2 W, and 3 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

63..178

PF03462 PCRF domain

PMID:19920124[8]

Domain

208..321

PF00472 RF-1 domain

PMID:19920124[8]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=prfA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16129174

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:949002

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0004066

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A7I0

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10761

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10761

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:949002

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000752

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0754

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  8. ↑ 8.0 8.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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