ppa:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

Ppa

Synonyms

inorganic pyrophosphatase[1], B4226[2][1], Ppa[2][1] , ECK4222, JW4185, b4226

Product description

Ppa[2][3];

Component of inorganic pyrophosphatase[3]

Inorganic pyrophosphatase; binds Zn(II); homohexameric, dimer of trimers[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000287

magnesium ion binding

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00209

F

Seeded from EcoCyc (v14.0)

complete

GO:0000287

magnesium ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008162

F

Seeded from EcoCyc (v14.0)

complete

GO:0000287

magnesium ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0460

F

Seeded from EcoCyc (v14.0)

complete

GO:0004427

inorganic diphosphatase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00209

F

Seeded from EcoCyc (v14.0)

complete

GO:0004427

inorganic diphosphatase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008162

F

Seeded from EcoCyc (v14.0)

complete

GO:0004427

inorganic diphosphatase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.6.1.1

F

Seeded from EcoCyc (v14.0)

complete

GO:0005829

cytosol

PMID:16858726[5]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0006796

phosphate metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008162

P

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

PMID:16858726[5]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0016787

hydrolase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0378

F

Seeded from EcoCyc (v14.0)

complete

GO:0008270

zinc ion binding

PMID:11985624[6]

IDA: Inferred from Direct Assay

F

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of inorganic pyrophosphatase

could be indirect

Protein

dnaK

PMID:15690043[7]

Experiment(s):EBI-889390

Protein

dnaN

PMID:15690043[7]

Experiment(s):EBI-889390

Protein

groL

PMID:15690043[7]

Experiment(s):EBI-889390

Protein

hldD

PMID:15690043[7]

Experiment(s):EBI-889390

Protein

rplD

PMID:15690043[7]

Experiment(s):EBI-889390, EBI-894403

Protein

tufA

PMID:15690043[7]

Experiment(s):EBI-889390

Protein

tig

PMID:15690043[7]

Experiment(s):EBI-889390, EBI-894403

Protein

atoD

PMID:15690043[7]

Experiment(s):EBI-894403

Protein

katG

PMID:15690043[7]

Experiment(s):EBI-894403

Protein

rplC

PMID:15690043[7]

Experiment(s):EBI-894403

Protein

rplI

PMID:15690043[7]

Experiment(s):EBI-894403

Protein

rplM

PMID:15690043[7]

Experiment(s):EBI-894403

Protein

rplN

PMID:15690043[7]

Experiment(s):EBI-894403

Protein

rplS

PMID:15690043[7]

Experiment(s):EBI-894403

Protein

rplV

PMID:15690043[7]

Experiment(s):EBI-894403

Protein

rpmB

PMID:15690043[7]

Experiment(s):EBI-894403

Protein

rpsB

PMID:15690043[7]

Experiment(s):EBI-894403

Protein

rpsC

PMID:15690043[7]

Experiment(s):EBI-894403

Protein

rpsE

PMID:15690043[7]

Experiment(s):EBI-894403

Protein

rpsG

PMID:15690043[7]

Experiment(s):EBI-894403

Protein

rpsH

PMID:15690043[7]

Experiment(s):EBI-894403

Protein

rpsJ

PMID:15690043[7]

Experiment(s):EBI-894403

Protein

rpsN

PMID:15690043[7]

Experiment(s):EBI-894403

Protein

rpsT

PMID:15690043[7]

Experiment(s):EBI-894403

Protein

secB

PMID:15690043[7]

Experiment(s):EBI-894403

Protein

slyD

PMID:15690043[7]

Experiment(s):EBI-894403

Protein

ybgQ

PMID:15690043[7]

Experiment(s):EBI-894403

Protein

acpT

PMID:15690043[7]

Experiment(s):EBI-894403

Protein

actP

PMID:15690043[7]

Experiment(s):EBI-894403

Protein

yjgD

PMID:15690043[7]

Experiment(s):EBI-894403

Protein

degQ

PMID:16606699[8]

Experiment(s):EBI-1147698

Protein

msrA

PMID:16606699[8]

Experiment(s):EBI-1147698

Protein

rplJ

PMID:16606699[8]

Experiment(s):EBI-1147698

Protein

rhlE

PMID:16606699[8]

Experiment(s):EBI-1147698

Protein

dadA

PMID:16606699[8]

Experiment(s):EBI-1147698

Protein

hemG

PMID:16606699[8]

Experiment(s):EBI-1147698

Protein

rraB

PMID:19402753[9]

LCMS(ID Probability):99.0

Protein

groL

PMID:19402753[9]

MALDI(Z-score):17.053160

Protein

secB

PMID:19402753[9]

LCMS(ID Probability):99.0

Protein

katG

PMID:19402753[9]

LCMS(ID Probability):99.0

Protein

tig

PMID:19402753[9]

LCMS(ID Probability):99.0 MALDI(Z-score):17.053160

Protein

kdsB

PMID:19402753[9]

MALDI(Z-score):39.758856

Protein

rplD

PMID:19402753[9]

LCMS(ID Probability):99.0 MALDI(Z-score):17.053160

Protein

waaA

PMID:19402753[9]

MALDI(Z-score):37.837893

Protein

coaD

PMID:19402753[9]

MALDI(Z-score):25.440462

Protein

ybgQ

PMID:19402753[9]

LCMS(ID Probability):99.0

Protein

actP

PMID:19402753[9]

LCMS(ID Probability):99.0

Protein

acpT

PMID:19402753[9]

LCMS(ID Probability):99.0

Protein

atoD

PMID:19402753[9]

LCMS(ID Probability):99.0

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

cytoplasm

From EcoCyc[3]


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MSLLNVPAGK DLPEDIYVVI EIPANADPIK YEIDKESGAL FVDRFMSTAM FYPCNYGYIN
HTLSLDGDPV DVLVPTPYPL QPGSVIRCRP VGVLKMTDEA GEDAKLVAVP HSKLSKEYDH
IKDVNDLPEL LKAQIAHFFE HYKDLEKGKW VKVEGWENAE AAKAEIVASF ERAKNK
Length

176

Mol. Wt

19.703 kDa

pI

5.0 (calculated)

Extinction coefficient

22,920 - 23,170 (calc based on 8 Y, 2 W, and 2 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P0A7A9

Modification Site

142

phosphorylation site at Y142

probability greater than 75%

PMID:17938405[10]

Domain

17..175

PF00719 Inorganic pyrophosphatase

PMID:19920124[11]

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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=ppa taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16132048

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948748

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0013824

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A7A9

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10755

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10755

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948748

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000746

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0748

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed
  6. ↑ Katayama, A et al. (2002) Systematic search for zinc-binding proteins in Escherichia coli. Eur. J. Biochem. 269 2403-13 PubMed
  7. ↑ 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 7.12 7.13 7.14 7.15 7.16 7.17 7.18 7.19 7.20 7.21 7.22 7.23 7.24 7.25 7.26 7.27 7.28 7.29 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  8. ↑ 8.0 8.1 8.2 8.3 8.4 8.5 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  9. ↑ 9.00 9.01 9.02 9.03 9.04 9.05 9.06 9.07 9.08 9.09 9.10 9.11 9.12 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  10. ↑ Macek, B et al. (2008) Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation. Mol. Cell Proteomics 7 299-307 PubMed
  11. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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