pmrD:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
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| Standard Name |
pmrD |
|---|---|
| Gene Synonym(s) |
ECK2253, b2259, JW2254[1], JW2254 |
| Product Desc. |
polymyxin B resistance protein[2][3] Inactive two-component system connector protein homolog; Salmonella ortholog blocks dephosphorylation of PmrA(BasR) by PmrB(BasS)[4] |
| Product Synonyms(s) |
polymyxin resistance protein B[1], B2259[2][1], PmrD[2][1] , ECK2253, JW2254, b2259 |
| Function from GO |
<GO_nr /> |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity | |
| Quick Links |
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Notes
In Salmonella but not E. coli, low Mg(2+) PhoP-activated PmrD controls PmrA(BasR)/PmrB(BasS) activity post-translationally by binding to phospho-PmrA(BasR) and inhibiting its dephosphorylation but not its phosphotransfer, connecting the PhoPQ and PmrAB two-component systems and allowing for an amplified and persistent PmrAB response (Kato, 2007). E. coli pmrD is induced by low Mg(2+) in a PhoP-dependent manner, thus the E. coli prmD product itself is non-functional, as shown by the fact that replacing the E. coli chromosomal prmD with the Salmonella prmD confers the Salmonella low Mg(2+) response to E. coli (Winfield, 2004). Although PmrA represses pmrD transcription in Salmonella, pmrD is not regulated by pmrA in E. coli (Winfield, 2004). A Salmonella prmD mutation eliminates the polymyxin B resistance induced in low Mg(2+), and this defect is corrected by a complementing Salmonella prmD+ clone (Kox, 2000); prmD+ E. coli K-12 does not show low Mg(+2)-induced polymyxin B resistance at all (Kato, 2007). However, citing their unpublished results, Kox (2000) report that E. coli K-12 prmD can fully rescue the Salmonella prmD defect, and they conclude that prmD is function. Although this experimental result is not refuted, repeated or discussed in Kato (2007), it seems as if this unpublished observation has been retracted. PhoPQ regulon.[4]
References
- ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
