paaK:Gene Product(s)

From EcoliWiki
Jump to: navigation, search

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

PaaK

Synonyms

phenylacetyl-CoA ligase[1], B1398[2][1], PaaK[2][1] , ECK1395, JW5218, b1398

Product description

phenylacetate-CoA ligase[2][3]

Phenylacetic acid degradation[4]

EC number (for enzymes)

<protect></protect>

Notes

Function

[back to top]


<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005737

cytoplasm

C

Seeded from Riley et al 2006 [1].

Missing: evidence, reference

GO:0000166

nucleotide binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc (v14.0)

complete

GO:0003824

catalytic activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000873

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

Seeded from EcoCyc (v14.0)

complete

GO:0008152

metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000873

P

Seeded from EcoCyc (v14.0)

complete

GO:0016874

ligase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0436

F

Seeded from EcoCyc (v14.0)

complete

GO:0047475

phenylacetate-CoA ligase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:6.2.1.30

F

Seeded from EcoCyc (v14.0)

complete

GO:0047475

phenylacetate-CoA ligase activity

PMID:9748275[5]

IMP: Inferred from Mutant Phenotype

F

Table 2.

complete

GO:0016405

CoA-ligase activity

PMID:9748275[5]

IMP: Inferred from Mutant Phenotype

F

Table 2: PA-CoA ligase activity.

complete

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

rpmB

PMID:19402753[6]

LCMS(ID Probability):99.6

</protect>

Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

<protect></protect>

Notes

Structure and Physical Properties

[back to top]


<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc

MITNTKLDPI ETASVDELQA LQTQRLKWTL KHAYENVPMY RRKFDAAGVH PDDFRELSDL
RKFPCTTKQD LRDNYPFDTF AVPMEQVVRI HASSGTTGKP TVVGYTQNDI DNWANIVARS
LRAAGGSPKD KIHVAYGYGL FTGGLGAHYG AERLGATVIP MSGGQTEKQA QLIRDFQPDM
IMVTPSYCLN LIEELERQLG GDASGCSLRV GVFGAEPWTQ AMRKEIERRL GITALDIYGL
SEVMGPGVAM ECLETTDGPT IWEDHFYPEI VNPHDGTPLA DGEHGELLFT TLTKEALPVI
RYRTRDLTRL LPGTARTMRR MDRISGRSDD MLIIRGVNVF PSQLEEEIVK FEHLSPHYQL
EVNRRGHLDS LSVKVELKES SLTLTHEQRC QVCHQLRHRI KSMVGISTDV MIVNCGSIPR
SEGKACRVFD LRNIVGA
Length

437

Mol. Wt

48.952 kDa

pI

6.6 (calculated)

Extinction coefficient

39,880 - 40,880 (calc based on 12 Y, 4 W, and 8 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

65..355

PF00501 AMP-binding enzyme

PMID:19920124[7]

<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=paaK taxon=562,83333 </beststructure>

Models

View models at:

</protect>

Structure figures

<protect>

</protect>

Notes

Gene Product Resources

[back to top]


See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference

<protect></protect>

Notes

Accessions in Other Databases

[back to top]


See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16129359

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945963

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0004671

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P76085

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G6719

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG13745

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945963

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120003313

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB3508

Escherichia coli str. K-12 substr. MG1655

<protect></protect>

Notes

Links

[back to top]




References

[back to top]


See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. 5.0 5.1 Ferrández, A et al. (1998) Catabolism of phenylacetic acid in Escherichia coli. Characterization of a new aerobic hybrid pathway. J. Biol. Chem. 273 25974-86 PubMed
  6. Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  7. Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

[back to top]