nanC:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

NanC

Synonyms

N-acetylnuraminic acid outer membrane channel protein[1], NanC[2][1], B4311[2][1], YjhA[2][1] , ECK4302, JW5778, yjhA, b4311

Product description

N-acetylneuraminic acid outer membrane channel[2][3]

N-acetylneuraminic acid outer membrane channel protein[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

Seeded from EcoCyc (v14.0)

complete

GO:0006810

transport

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0813

P

Seeded from EcoCyc (v14.0)

complete

GO:0006811

ion transport

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0406

P

Seeded from EcoCyc (v14.0)

complete

GO:0008643

carbohydrate transport

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0762

P

Seeded from EcoCyc (v14.0)

complete

GO:0009279

cell outer membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0998

C

Seeded from EcoCyc (v14.0)

complete

GO:0009279

cell outer membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0040

C

Seeded from EcoCyc (v14.0)

complete

GO:0045203

integral to cell outer membrane

PMID:19796645[5]

IDA: Inferred from Direct Assay

C

complete

GO:0016020

membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

Seeded from EcoCyc (v14.0)

complete

GO:0015288

porin activity

PMID:15743943[6]

IMP: Inferred from Mutant Phenotype

F

complete

GO:0016021

integral to membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc (v14.0)

complete

GO:0015478

oligosaccharide transporting porin activity

PMID:15743943[6]

IMP: Inferred from Mutant Phenotype

F

complete

GO:0046930

pore complex

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0626

C

Seeded from EcoCyc (v14.0)

complete

GO:0015772

oligosaccharide transport

PMID:15743943[6]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0015136

sialic acid transmembrane transporter activity

PMID:15743943[6]

IMP: Inferred from Mutant Phenotype

F

complete

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc

MKFMKKAKIL SGVLLLCFSS PLISQAATLD VRGGYRSGSH AYETRLKVSE GWQNGWWASM
ESNTWNTIHD NKKENAALND VQVEVNYAIK LDDQWTVRPG MLTHFSSNGT RYGPYVKLSW
DATKDLNFGI RYRYDWKAYR QQDLSGDMSR DNVHRWDGYV TYHINSDFTF AWQTTLYSKQ
NDYRYANHKK WATENAFVLQ YHMTPDITPY IEYDYLDRQG VYNGRDNLSE NSYRIGVSFK L
Length

241

Mol. Wt

28.294 kDa

pI

9.1 (calculated)

Extinction coefficient

83,310 - 83,435 (calc based on 19 Y, 10 W, and 1 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

motif

1-23

UniProt Manual:Signal Peptides

UniProt:P69856

Domain

17..238

PF06178 Oligogalacturonate-specific porin protein (KdgM)

PMID:19920124[7]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=nanC taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:90111728

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:946843

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0014136

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P69856

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G7921

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG12389

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:946843

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120004416

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB2290

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. Wirth, C et al. (2009) NanC crystal structure, a model for outer-membrane channels of the acidic sugar-specific KdgM porin family. J. Mol. Biol. 394 718-31 PubMed
  6. 6.0 6.1 6.2 6.3 Condemine, G et al. (2005) Function and expression of an N-acetylneuraminic acid-inducible outer membrane channel in Escherichia coli. J. Bacteriol. 187 1959-65 PubMed
  7. Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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