mqsR:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

MqsR[1]

Synonyms

B3022[2][3], YgiU[2][3], MqsR[1], ECK3013, JW2990, ygiU, b3022

Product description

RNase interferase[4][5], Motility quorum-sensing regulator[1], Toxin mitigted by MqsA (YgiT) antitoxin[4][6], works through QseBC and AI-2[1], First identified as induced in biofilms[7], 2nd protein to be identified that when deleted, decreases persistence[8]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004521

endoribonuclease activity

PMID:19690171[5]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0005515

protein binding

PMID:19690171[5]

IPI: Inferred from Physical Interaction

UniProtKB:Q46864

F

Seeded from EcoCyc (v14.0)

complete

GO:0009372

quorum sensing

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0673

P

Seeded from EcoCyc (v14.0)

complete

GO:0017148

negative regulation of translation

PMID:19690171[5]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc (v14.0)

complete

GO:0043488

regulation of mRNA stability

PMID:19690171[5]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc (v14.0)

complete

GO:0044010

single-species biofilm formation

PMID:16352847[1]

IMP: Inferred from Mutant Phenotype

P

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

yfdP

PMID:16606699[9]

Experiment(s):EBI-1144562

Protein

yahO

PMID:16606699[9]

Experiment(s):EBI-1144562

Protein

yqjK

PMID:16606699[9]

Experiment(s):EBI-1144562

Protein

ygbA

PMID:16606699[9]

Experiment(s):EBI-1144562

Protein

ihfA

PMID:16606699[9]

Experiment(s):EBI-1144562

Protein

rpsC

PMID:16606699[9]

Experiment(s):EBI-1144562

Protein

groL

PMID:16606699[9]

Experiment(s):EBI-1144562

Protein

ygfX

PMID:16606699[9]

Experiment(s):EBI-1144562

Protein

tnaA

PMID:16606699[9]

Experiment(s):EBI-1144562

Protein

ybaA

PMID:16606699[9]

Experiment(s):EBI-1144562
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MEKRTPHTRL SQVKKLVNAG QVRTTRSALL NADELGLDFD GMCNVIIGLS ESDFYKSMTT
YSDHTIWQDV YRPRLVTGQV YLKITVIHDV LIVSFKEK
Length

98

Mol. Wt

11.231 kDa

pI

9.1 (calculated)

Extinction coefficient

11,460 - 11,585 (calc based on 4 Y, 1 W, and 1 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References
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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=mqsR taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16130918

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947500

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0009925

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:Q46865

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G7572

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG13023

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947500

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120004130

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB2841

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 González Barrios, AF et al. (2006) Autoinducer 2 controls biofilm formation in Escherichia coli through a novel motility quorum-sensing regulator (MqsR, B3022). J. Bacteriol. 188 305-16 PubMed
  2. ↑ 2.0 2.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  4. ↑ 4.0 4.1 Brown, BL et al. (2009) Three dimensional structure of the MqsR:MqsA complex: a novel TA pair comprised of a toxin homologous to RelE and an antitoxin with unique properties. PLoS Pathog. 5 e1000706 PubMed
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Yamaguchi, Y et al. (2009) MqsR, a crucial regulator for quorum sensing and biofilm formation, is a GCU-specific mRNA interferase in Escherichia coli. J. Biol. Chem. 284 28746-53 PubMed
  6. ↑ Zhang, XS et al. (2008) Escherichia coli transcription factor YncC (McbR) regulates colanic acid and biofilm formation by repressing expression of periplasmic protein YbiM (McbA). ISME J 2 615-31 PubMed
  7. ↑ Ren, D et al. (2004) Gene expression in Escherichia coli biofilms. Appl. Microbiol. Biotechnol. 64 515-24 PubMed
  8. ↑ Kim, Y & Wood, TK (2010) Toxins Hha and CspD and small RNA regulator Hfq are involved in persister cell formation through MqsR in Escherichia coli. Biochem. Biophys. Res. Commun. 391 209-13 PubMed
  9. ↑ 9.0 9.1 9.2 9.3 9.4 9.5 9.6 9.7 9.8 9.9 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed

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