mpaA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

MpaA

Synonyms

murein peptide amidase A[1], B1326[2][1], YcjI[2][1], MpaA[2][1] , ECK1322, JW1319, ycjI, b1326

Product description

murein peptide amidase A[2][3]

Murein tripeptide hydrolysis, cleaves glutamyl-DAP bond; cytoplasmic enzyme probably responsible for the degardation of murein tripeptide that is not recycled[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004181

metallocarboxypeptidase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000834

F

Seeded from EcoCyc (v14.0)

complete

GO:0006508

proteolysis

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000834

P

Seeded from EcoCyc (v14.0)

complete

GO:0008270

zinc ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000834

F

Seeded from EcoCyc (v14.0)

complete

GO:0004040

amidase activity

PMID:12511517[5]

IGI: Inferred from Genetic Interaction

EcoliWiki:mpl


F

complete

GO:0009253

peptidoglycan catabolic process

PMID:12511517[5]

IGI: Inferred from Genetic Interaction

EcoliWiki:mpl


P

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

gadW

PMID:16606699[6]

Experiment(s):EBI-1139559

Protein

groL

PMID:16606699[6]

Experiment(s):EBI-1139559

Protein

dnaK

PMID:16606699[6]

Experiment(s):EBI-1139559
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

cytoplasm

From EcoCyc[3]


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MIIRKICTTL PVILPEPETI MTVTRPRAER GAFPPGTEHY GRSLLGAPLI WFPAPAASRE
SGLILAGTHG DENSSVVTLS CALRTLTPSL RRHHVVLCVN PDGCQLGLRA NANGVDLNRN
FPAANWKEGE TVYRWNSAAE ERDVVLLTGD KPGSEPETQA LCQLIHRIQP AWVVSFHDPL
ACIEDPRHSE LGEWLAQAFE LPLVTSVGYE TPGSFGSWCA DLNLHCITAE FPPISSDEAS
EKYLFAMANL LRWHPKDAIR PS
Length

262

Mol. Wt

28.82 kDa

pI

5.8 (calculated)

Extinction coefficient

44,460 - 45,460 (calc based on 4 Y, 7 W, and 8 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

35..205

PF00246 Zinc carboxypeptidase

PMID:19920124[7]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=mpaA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:226524711

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945969

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0004450

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0ACV6

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G6662

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG13906

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945969

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120003257

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB3665

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 Uehara, T & Park, JT (2003) Identification of MpaA, an amidase in Escherichia coli that hydrolyzes the gamma-D-glutamyl-meso-diaminopimelate bond in murein peptides. J. Bacteriol. 185 679-82 PubMed
  6. ↑ 6.0 6.1 6.2 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  7. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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