menE:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

MenE

Synonyms

o-succinylbenzoate-CoA ligase[1], B2260[2][1], MenE[2][1] , ECK2254, JW2255, b2260

Product description

MenE[2][3];

Component of O-succinylbenzoic acid-CoA ligase[2]; o-succinylbenzoate-CoA ligase[3]

o-succinylbenzoate-CoA synthase; homotetrameric; menaquinone biosynthesis[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005737

cytoplasm

C

Seeded from Riley et al 2006 [1].

Missing: evidence, reference

GO:0000166

nucleotide binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

Seeded from EcoCyc (v14.0)

complete

GO:0008756

o-succinylbenzoate-CoA ligase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010192

F

Seeded from EcoCyc (v14.0)

complete

GO:0008756

o-succinylbenzoate-CoA ligase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:6.2.1.26

F

Seeded from EcoCyc (v14.0)

complete

GO:0009234

menaquinone biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010192

P

Seeded from EcoCyc (v14.0)

complete

GO:0009234

menaquinone biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0474

P

Seeded from EcoCyc (v14.0)

complete

GO:0008756

o-succinylbenzoate-CoA ligase activity

PMID:8626063[5]

IDA: Inferred from Direct Assay

F

complete

GO:0008756

o-succinylbenzoate-CoA ligase activity

PMID:9324253[6]

IDA: Inferred from Direct Assay

F

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of O-succinylbenzoic acid-CoA ligase

could be indirect

Protein

iscS

PMID:16606699[7]

Experiment(s):EBI-1142364

Protein

ndpA

PMID:16606699[7]

Experiment(s):EBI-1142364

Protein

nadE

PMID:16606699[7]

Experiment(s):EBI-1142364

Protein

menF

PMID:19402753[8]

MALDI(Z-score):44.087697

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MIFSDWPWRH WRQVRGETIA LRLNDEQLNW RELCARVDEL ASGFAVQGVV EGSGVMLRAW
NTPQTLLAWL ALLQCGARVL PVNPQLPQPL LEELLPNLTL QFALVPDGEN TFPALTSLHI
QLVEGAHAAT WQPTRLCSMT LTSGSTGLPK AAVHTYQAHL ASAQGVLSLI PFGDHDDWLL
SLPLFHVSGQ GIMWRWLYAG ARMTVRDKQP LEQMLAGCTH ASLVPTQLWR LLVNRSSVSL
KAVLLGGAAI PVELTEQARE QGIRCFCGYG LTEFASTVCA KEADGLADVG SPLPGREVKI
VNNEVWLRAA SMAEGYWRNG QLVSLVNDEG WYATRDRGEM HNGKLTIVGR LDNLFFSGGE
GIQPEEVERV IAAHPAVLQV FIVPVADKEF GHRPVAVMEY DHESVDLSEW VKDKLARFQQ
PVRWLTLPPE LKNGGIKISR QALKEWVQRQ Q
Length

451

Mol. Wt

50.183 kDa

pI

6.4 (calculated)

Extinction coefficient

102,440 - 103,315 (calc based on 6 Y, 17 W, and 7 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

29..382

PF00501 AMP-binding enzyme

PMID:19920124[9]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=menE taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16130195

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:946741

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0007471

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P37353

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG12437

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG12437

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:946741

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120002291

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB2332

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Sharma, V et al. (1996) Menaquinone (vitamin K2) biosynthesis: localization and characterization of the menE gene from Escherichia coli. Gene 168 43-8 PubMed
  6. ↑ Bhattacharyya, DK et al. (1997) Vitamin K2 (menaquinone) biosynthesis in Escherichia coli: evidence for the presence of an essential histidine residue in o-succinylbenzoyl coenzyme A synthetase. J. Bacteriol. 179 6061-5 PubMed
  7. ↑ 7.0 7.1 7.2 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  8. ↑ Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  9. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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