mazF:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

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Standard name

MazF

Synonyms

toxin of the ChpA-ChpR toxin-antitoxin system, endoribonuclease, B2782, MazF, ChpA, ChpAK , chpA, chpAK, ECK2776, JW2753, b2782

Product description

toxin of the MazEF "addiction module" that exhibits ribonuclease activity; MazF toxin of the MazF-MazE toxin-antitoxin system that exhibits ribonuclease activity;

Component of MazF toxin of the MazF-MazE toxin-antitoxin system that exhibits ribonuclease activity; MazE-MazF complex

MazF toxin and mRNA interferase, antitoxin is MazE; inhibitor of translation by mRNA cleavage

EC number (for enzymes)

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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki. See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003677

DNA binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003477

F

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

Seeded from EcoCyc (v14.0)

complete

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of MazF toxin of the MazF-MazE toxin-antitoxin system that exhibits ribonuclease activity

could be indirect

Protein

yibL

PMID:16606699[1]

Experiment(s):EBI-1143931

Protein

Subunits of MazE-MazF complex

could be indirect


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Notes

Localization

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Compartment Description Evidence Reference/Source Notes

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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc

MVSRYVPDMG DLIWVDFDPT KGSEQAGHRP AVVLSPFMYN NKTGMCLCVP CTTQSKGYPF
EVVLSGQERD GVALADQVKS IAWRARGATK KGTVAPEELQ LIKAKINVLI G
Length

111

Mol. Wt

12.097 kDa

pI

8.4 (calculated)

Extinction coefficient

15,470 - 15,845 (calc based on 3 Y, 2 W, and 3 C residues)

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Domains/Motifs/Modification Sites

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Type Residues Description Notes References

Domain

8..110

PF02452 PemK-like protein

PMID:19920124[2]

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

<motif_map/>

Structure
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Structures

<beststructure> gene=chpA taxon=562,83333 </beststructure>

Models

View models at:

See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

</protect>

Structure figures

<protect>

</protect>

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16130689

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947252

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0AE70

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947252

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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  1. Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  2. Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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