lrhA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

LrhA

Synonyms

DNA-binding transcriptional repressor of flagellar, motility and chemotaxis genes[1], B2289[2][1], GenR[2][1], LrhA[2][1] , ECK2283, genR, JW2284, b2289

Product description

LrhA transcriptional repressor[2]; LrhA transcriptional dual regulator[3]

Transcriptional repressor of flagellar and motility master regulator FlhDC; autoregulator; mutation confers lower RpoS levels, modulates rssB activity[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003700

transcription factor activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000847

F

Seeded from EcoCyc (v14.0)

complete

GO:0006350

transcription

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0804

P

Seeded from EcoCyc (v14.0)

complete

GO:0006355

regulation of transcription, DNA-dependent

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000847

P

Seeded from EcoCyc (v14.0)

complete

GO:0043565

sequence-specific DNA binding

PMID:12123461[5]

IDA: Inferred from Direct Assay

F

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence
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Notes

Localization

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Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MISANRPIIN LDLDLLRTFV AVADLNTFAA AAAAVCRTQS AVSQQMQRLE QLVGKELFAR
HGRNKLLTEH GIQLLGYARK ILRFNDEACS SLMFSNLQGV LTIGASDESA DTILPFLLNR
VSSVYPKLAL DVRVKRNAYM AEMLESQEVD LMVTTHRPSA FKALNLRTSP THWYCAAEYI
LQKGEPIPLV LLDDPSPFRD MVLATLNKAD IPWRLAYVAS TLPAVRAAVK AGLGVTARPV
EMMSPDLRVL SGVDGLPPLP DTEYLLCYDP SSNNELAQVI YQAMESYHNP WQYSPMSAPE
GDDSLLIERD IE
Length

312

Mol. Wt

34.594 kDa

pI

5.1 (calculated)

Extinction coefficient

32,890 - 33,390 (calc based on 11 Y, 3 W, and 4 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

95..288

PF03466 LysR substrate binding domain

PMID:19920124[6]

Domain

13..72

PF00126 Bacterial regulatory helix-turn-helix protein, lysR family

PMID:19920124[6]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=lrhA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16130224

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:946769

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0007555

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P36771

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG12123

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG12123

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:946769

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120002026

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB2044

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Lehnen, D et al. (2002) LrhA as a new transcriptional key regulator of flagella, motility and chemotaxis genes in Escherichia coli. Mol. Microbiol. 45 521-32 PubMed
  6. ↑ 6.0 6.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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