lpxM:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

LpxM

Synonyms

myristoyl-acyl carrier protein (ACP)-dependent acyltransferase[1], B1855[2][1], WaaN[2][1], Mlt[2][1], LpxM[2][1], MsbB[2][1] , ECK1856, JW1844, mlt, msbB, waaN, b1855

Product description

Lipid A biosynthesis; KDO2-lauroyl-lipid IVA myristoyl-ACP acyltransferase[3]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0031225

anchored to membrane

C

Seeded from Riley et al 2006 [1].

Missing: evidence, reference

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0997

C

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

Seeded from EcoCyc (v14.0)

complete

GO:0008415

acyltransferase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004960

F

Seeded from EcoCyc (v14.0)

complete

GO:0008415

acyltransferase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0012

F

Seeded from EcoCyc (v14.0)

complete

GO:0009103

lipopolysaccharide biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011921

P

Seeded from EcoCyc (v14.0)

complete

GO:0009103

lipopolysaccharide biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0448

P

Seeded from EcoCyc (v14.0)

complete

GO:0009244

lipopolysaccharide core region biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004960

P

Seeded from EcoCyc (v14.0)

complete

GO:0009276

Gram-negative-bacterium-type cell wall

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011921

C

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004960

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011921

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-9904

C

Seeded from EcoCyc (v14.0)

complete

GO:0016740

transferase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

Seeded from EcoCyc (v14.0)

complete

GO:0016747

transferase activity, transferring acyl groups other than amino-acyl groups

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011921

F

Seeded from EcoCyc (v14.0)

complete

GO:0042280

cell surface antigen activity, host-interacting

F

Seeded from Riley et al 2006 [1].

Missing: evidence, reference

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

groL

PMID:16606699[4]

Experiment(s):EBI-1141045

Protein

alaS

PMID:16606699[4]

Experiment(s):EBI-1141045

Protein

glpD

PMID:16606699[4]

Experiment(s):EBI-1141045

Protein

ymfG

PMID:16606699[4]

Experiment(s):EBI-1141045

Protein

relE

PMID:16606699[4]

Experiment(s):EBI-1141045

Protein

ahpF

PMID:16606699[4]

Experiment(s):EBI-1141045

Protein

fusA

PMID:16606699[4]

Experiment(s):EBI-1141045

Protein

rpsM

PMID:16606699[4]

Experiment(s):EBI-1141045

Protein

recB

PMID:16606699[4]

Experiment(s):EBI-1141045

Protein

aceE

PMID:16606699[4]

Experiment(s):EBI-1141045

Protein

zwf

PMID:16606699[4]

Experiment(s):EBI-1141045

Protein

gyrA

PMID:16606699[4]

Experiment(s):EBI-1141045

Protein

clpB

PMID:16606699[4]

Experiment(s):EBI-1141045

Protein

glnD

PMID:16606699[4]

Experiment(s):EBI-1141045

Protein

htrB

PMID:16606699[4]

Experiment(s):EBI-1141045

Protein

acnB

PMID:16606699[4]

Experiment(s):EBI-1141045

Protein

ymfM

PMID:16606699[4]

Experiment(s):EBI-1141045

Protein

nuoG

PMID:16606699[4]

Experiment(s):EBI-1141045

Protein

topA

PMID:16606699[4]

Experiment(s):EBI-1141045

Protein

fliY

PMID:16606699[4]

Experiment(s):EBI-1141045
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

plasma membrane

From EcoCyc[5]


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

METKKNNSEY IPEFDKSFRH PRYWGAWLGV AAMAGIALTP PKFRDPILAR LGRFAGRLGK
SSRRRALINL SLCFPERSEA EREAIVDEMF ATAPQAMAMM AELAIRGPEK IQPRVDWQGL
EIIEEMRRNN EKVIFLVPHG WAVDIPAMLM ASQGQKMAAM FHNQGNPVFD YVWNTVRRRF
GGRLHARNDG IKPFIQSVRQ GYWGYYLPDQ DHGPEHSEFV DFFATYKATL PAIGRLMKVC
RARVVPLFPI YDGKTHRLTI QVRPPMDDLL EADDHTIARR MNEEVEIFVG PRPEQYTWIL
KLLKTRKPGE IQPYKRKDLY PIK
Length

323

Mol. Wt

37.411 kDa

pI

10.0 (calculated)

Extinction coefficient

54,890 - 55,140 (calc based on 11 Y, 7 W, and 2 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

11..305

PF03279 Bacterial lipid A biosynthesis acyltransferase

PMID:19920124[6]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=lpxM taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16129808

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945143

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0006185

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P24205

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10614

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10614

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945143

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000607

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0609

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  4. ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 4.15 4.16 4.17 4.18 4.19 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  5. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  6. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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