lpxH:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

LpxH

Synonyms

UDP-2,3-diacylglucosamine pyrophosphatase[1], B0524[2][1], YbbF[2][1], LpxH[2][1] , ECK0517, JW0513, ybbF, b0524

Product description

EG12666[2][3]

Lipid A biosynthesis, UDP-2,3-diacylglucosamine pyrophosphatase[4]

EC number (for enzymes) 
3.6.1.-[1]
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005737

cytoplasm

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00575

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010138

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0009245

lipid A biosynthetic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00575

P

Seeded from EcoCyc (v14.0)

complete

GO:0009245

lipid A biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010138

P

Seeded from EcoCyc (v14.0)

complete

GO:0008758

UDP-2,3-diacylglucosamine hydrolase activity

PMID:12000771[5]

IMP: Inferred from Mutant Phenotype

F

complete

GO:0009245

lipid A biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0441

P

Seeded from EcoCyc (v14.0)

complete

GO:0009245

lipid A biosynthetic process

PMID:12000771[5]

IMP: Inferred from Mutant Phenotype

P

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

rplQ

PMID:16606699[6]

Experiment(s):EBI-1137052

Protein

rtcB

PMID:16606699[6]

Experiment(s):EBI-1137052

Protein

ydcS

PMID:16606699[6]

Experiment(s):EBI-1137052

Protein

pheA

PMID:16606699[6]

Experiment(s):EBI-1137052

Protein

dacC

PMID:16606699[6]

Experiment(s):EBI-1137052

Protein

groL

PMID:16606699[6]

Experiment(s):EBI-1137052

Protein

ihfA

PMID:16606699[6]

Experiment(s):EBI-1137052

Protein

fliI

PMID:16606699[6]

Experiment(s):EBI-1137052

Protein

hycF

PMID:16606699[6]

Experiment(s):EBI-1137052

Protein

glpD

PMID:16606699[6]

Experiment(s):EBI-1137052

Protein

hflB

PMID:16606699[6]

Experiment(s):EBI-1137052

Protein

rplD

PMID:16606699[6]

Experiment(s):EBI-1137052

Protein

crl

PMID:16606699[6]

Experiment(s):EBI-1137052

Protein

yneG

PMID:16606699[6]

Experiment(s):EBI-1137052

Protein

intS

PMID:16606699[6]

Experiment(s):EBI-1137052

Protein

rrmA

PMID:16606699[6]

Experiment(s):EBI-1137052

Protein

ygjQ

PMID:16606699[6]

Experiment(s):EBI-1137052

Protein

dadA

PMID:16606699[6]

Experiment(s):EBI-1137052

Protein

rpsS

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rpsM

PMID:19402753[7]

LCMS(ID Probability):99.6

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MATLFIADLH LCVEEPAITA GFLRFLAGEA RKADALYILG DLFEAWIGDD DPNPLHRKMA
AAIKAVSDSG VPCYFIHGNR DFLLGKRFAR ESGMTLLPEE KVLELYGRRV LIMHGDTLCT
DDAGYQAFRA KVHKPWLQTL FLALPLFVRK RIAARMRANS KEANSSKSLA IMDVNQNAVV
SAMEKHQVQW LIHGHTHRPA VHELIANQQP AFRVVLGAWH TEGSMVKVTA DDVELIHFPF
Length

240

Mol. Wt

26.894 kDa

pI

7.7 (calculated)

Extinction coefficient

27,960 - 28,335 (calc based on 4 Y, 4 W, and 3 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

1..199

PF00149 Calcineurin-like phosphoesterase

PMID:19920124[8]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=lpxH taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128508

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:949053

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0001804

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P43341

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG12666

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG12666

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:949053

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120002352

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB2532

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 Babinski, KJ et al. (2002) Accumulation of the lipid A precursor UDP-2,3-diacylglucosamine in an Escherichia coli mutant lacking the lpxH gene. J. Biol. Chem. 277 25947-56 PubMed
  6. ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 6.12 6.13 6.14 6.15 6.16 6.17 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  7. ↑ 7.0 7.1 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  8. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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