leuD:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

LeuD

Synonyms

3-isopropylmalate isomerase subunit[1], B0071[2][1], LeuD[2][1] , ECK0073, JW0070, b0071

Product description

LeuD[2][3];

Component of isopropylmalate isomerase[2][3]

alpha-Isopropylmalate isomerase small subunit[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003861

3-isopropylmalate dehydratase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01031

F

Seeded from EcoCyc (v14.0)

complete

GO:0003861

3-isopropylmalate dehydratase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004431

F

Seeded from EcoCyc (v14.0)

complete

GO:0003861

3-isopropylmalate dehydratase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012305

F

Seeded from EcoCyc (v14.0)

complete

GO:0009316

3-isopropylmalate dehydratase complex

PMID:4587614[5]

IMP: Inferred from Mutant Phenotype

C

Extracts from mutant cells lack the activity.

complete

GO:0003861

3-isopropylmalate dehydratase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:4.2.1.33

F

Seeded from EcoCyc (v14.0)

complete

GO:0009098

leucine biosynthetic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01031

P

Seeded from EcoCyc (v14.0)

complete

GO:0009098

leucine biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004431

P

Seeded from EcoCyc (v14.0)

complete

GO:0009098

leucine biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012305

P

Seeded from EcoCyc (v14.0)

complete

GO:0009098

leucine biosynthetic process

PMID:4570778[6]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0009316

3-isopropylmalate dehydratase complex

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004431

C

Seeded from EcoCyc (v14.0)

complete

GO:0009316

3-isopropylmalate dehydratase complex

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012305

C

Seeded from EcoCyc (v14.0)

complete

GO:0016829

lyase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0456

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of isopropylmalate isomerase

could be indirect

Protein

pflB

PMID:16606699[7]

Experiment(s):EBI-1135498

Protein

ytfE

PMID:16606699[7]

Experiment(s):EBI-1135498

Protein

dnaK

PMID:16606699[7]

Experiment(s):EBI-1135498

Protein

inaA

PMID:16606699[7]

Experiment(s):EBI-1135498

Protein

rpsP

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

ppsA

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

talB

PMID:19402753[8]

LCMS(ID Probability):99.6

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MAEKFIKHTG LVVPLDAANV DTDAIIPKQF LQKVTRTGFG AHLFNDWRFL DEKGQQPNPD
FVLNFPQYQG ASILLARENF GCGSSREHAP WALTDYGFKV VIAPSFADIF YGNSFNNQLL
PVKLSDAEVD ELFALVKANP GIHFDVDLEA QEVKAGEKTY RFTIDAFRRH CMMNGLDSIG
LTLQHDDAIA AYEAKQPAFM N
Length

201

Mol. Wt

22.487 kDa

pI

5.1 (calculated)

Extinction coefficient

18,450 - 18,700 (calc based on 5 Y, 2 W, and 2 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P30126

Domain

2..127

PF00694 Aconitase C-terminal domain

PMID:19920124[9]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=leuD taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128065

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945642

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0000259

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P30126

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11575

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11575

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945642

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001527

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1535

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Yang, HL & Kessler, DP (1974) Genetic analysis of the leucine region in Escherichia coli B-r: gene-enzyme assignments. J. Bacteriol. 117 63-72 PubMed
  6. ↑ Somers, JM et al. (1973) Genetic fine structure of the leucine operon of Escherichia coli K-12. J. Bacteriol. 113 1268-72 PubMed
  7. ↑ 7.0 7.1 7.2 7.3 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  8. ↑ 8.0 8.1 8.2 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  9. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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