kdsB:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

KdsB

Synonyms

3-deoxy-manno-octulosonate cytidylyltransferase[1], B0918[2][1], KdsB[2][1] , ECK0909, JW0901, b0918

Product description

CPM- 3-deoxy-manno-octulosonate cytidylyltransferase; LPS biosynthesis[3]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000287

magnesium ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0460

F

Seeded from EcoCyc (v14.0)

complete

GO:0000287

magnesium ion binding

PMID:19815542[4]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00057

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004528

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0008690

3-deoxy-manno-octulosonate cytidylyltransferase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00057

F

Seeded from EcoCyc (v14.0)

complete

GO:0008690

3-deoxy-manno-octulosonate cytidylyltransferase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004528

F

Seeded from EcoCyc (v14.0)

complete

GO:0008690

3-deoxy-manno-octulosonate cytidylyltransferase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.7.7.38

F

Seeded from EcoCyc (v14.0)

complete

GO:0019294

keto-3-deoxy-D-manno-octulosonic acid biosynthetic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00057

P

Seeded from EcoCyc (v14.0)

complete

GO:0019294

keto-3-deoxy-D-manno-octulosonic acid biosynthetic process

PMID:2989246[5]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

tufA

PMID:15690043[6]

Experiment(s):EBI-881333

Protein

dnaJ

PMID:15690043[6]

Experiment(s):EBI-888863

Protein

dnaK

PMID:15690043[6]

Experiment(s):EBI-888863

Protein

hupB

PMID:15690043[6]

Experiment(s):EBI-888863

Protein

pepB

PMID:15690043[6]

Experiment(s):EBI-888863

Protein

rplD

PMID:15690043[6]

Experiment(s):EBI-888863

Protein

rplK

PMID:15690043[6]

Experiment(s):EBI-888863

Protein

rplL

PMID:15690043[6]

Experiment(s):EBI-888863

Protein

rpsA

PMID:15690043[6]

Experiment(s):EBI-888863

Protein

yfbS

PMID:15690043[6]

Experiment(s):EBI-888863

Protein

yjaH

PMID:15690043[6]

Experiment(s):EBI-888863

Protein

dcuR

PMID:15690043[6]

Experiment(s):EBI-888863

Protein

nadE

PMID:16606699[7]

Experiment(s):EBI-1138355

Protein

sdhA

PMID:16606699[7]

Experiment(s):EBI-1138355

Protein

dcuR

PMID:19402753[8]

LCMS(ID Probability):99.0

Protein

yfbS

PMID:19402753[8]

LCMS(ID Probability):99.0

Protein

yjaH

PMID:19402753[8]

LCMS(ID Probability):99.0

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

cytoplasm

From EcoCyc[9]


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MSFVVIIPAR YASTRLPGKP LVDINGKPMI VHVLERARES GAERIIVATD HEDVARAVEA
AGGEVCMTRA DHQSGTERLA EVVEKCAFSD DTVIVNVQGD EPMIPATIIR QVADNLAQRQ
VGMATLAVPI HNAEEAFNPN AVKVVLDAEG YALYFSRATI PWDRDRFAEG LETVGDNFLR
HLGIYGYRAG FIRRYVNWQP SPLEHIEMLE QLRVLWYGEK IHVAVAQEVP GTGVDTPEDL
ERVRAEMR
Length

248

Mol. Wt

27.613 kDa

pI

5.1 (calculated)

Extinction coefficient

26,930 - 27,180 (calc based on 7 Y, 3 W, and 2 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P04951

Domain

4..221

PF02348 Cytidylyltransferase

PMID:19920124[10]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=kdsB taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128885

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945539

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0003122

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P04951

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10519

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10519

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945539

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000512

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0514

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  4. ↑ Heyes, DJ et al. (2009) Structure-based mechanism of CMP-2-keto-3-deoxymanno-octulonic acid synthetase: convergent evolution of a sugar-activating enzyme with DNA/RNA polymerases. J. Biol. Chem. 284 35514-23 PubMed
  5. ↑ Goldman, RC & Kohlbrenner, WE (1985) Molecular cloning of the structural gene coding for CTP:CMP-3-deoxy-manno-octulosonate cytidylyltransferase from Escherichia coli K-12. J. Bacteriol. 163 256-61 PubMed
  6. ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  7. ↑ 7.0 7.1 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  8. ↑ 8.0 8.1 8.2 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  9. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  10. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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