kdgR:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

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Standard name

KdgR

Synonyms

predicted DNA-binding transcriptional regulator[1], B1827[2][1], YebP[2][1], KdgR[2][1] , ECK1826, JW1816, yebP, b1827

Product description

KdgR transcriptional repressor[2][3]

Regulator of kdgK, kdgT, eda; possibly regulates several other genes, e.g. yjgK[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003700

transcription factor activity

PMID:15659677[5]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0003700

transcription factor activity

PMID:4359651[6]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0003700

transcription factor activity

PMID:4359651[6]

IMP: Inferred from Mutant Phenotype

F

Seeded from EcoCyc (v14.0)

complete

GO:0016566

specific transcriptional repressor activity

PMID:15659677[5]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0016566

specific transcriptional repressor activity

PMID:4359651[6]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0016566

specific transcriptional repressor activity

PMID:4359651[6]

IMP: Inferred from Mutant Phenotype

F

Seeded from EcoCyc (v14.0)

complete

GO:0032582

negative regulation of gene-specific transcription

PMID:15659677[5]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc (v14.0)

complete

GO:0032582

negative regulation of gene-specific transcription

PMID:4359651[6]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc (v14.0)

complete

GO:0032582

negative regulation of gene-specific transcription

PMID:4359651[6]

IMP: Inferred from Mutant Phenotype

P

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

ihfA

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

slyD

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

lipA

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rpoD

PMID:19402753[7]

LCMS(ID Probability):99.5

Protein

ymfD

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

malP

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

hns

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

topA

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rdgC

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

fis

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

polA

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rpoB

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

xseB

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

uvrA

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

hupA

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

manX

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rpoA

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rpoC

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

ynjE

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rpoH

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

yciT

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

purR

PMID:19402753[7]

LCMS(ID Probability):99.6

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MANADLDKQP DSVSSVLKVF GILQALGEER EIGITELSQR VMMSKSTVYR FLQTMKTLGY
VAQEGESEKY SLTLKLFELG ARALQNVDLI RSADIQMREL SRLTKETIHL GALDEDSIVY
IHKIDSMYNL RMYSRIGRRN PLYSTAIGKV LLAWRDRDEV KQILEGVEYK RSTERTITST
EALLPVLDQV REQGYGEDNE EQEEGLRCIA VPVFDRFGVV IAGLSISFPT LRFSEERLQE
YVAMLHTAAR KISAQMGYHD YPF
Length

263

Mol. Wt

30.029 kDa

pI

5.4 (calculated)

Extinction coefficient

23,380 - 23,505 (calc based on 12 Y, 1 W, and 1 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Modification Site

12

phosphorylation site at S12

probability less than 75%

PMID:17938405[8]

Modification Site

14

phosphorylation site at S14

probability less than 75%

PMID:17938405[8]

Modification Site

15

phosphorylation site at S15

probability less than 75%

PMID:17938405[8]

Domain

128..255

PF01614 Bacterial transcriptional regulator

PMID:19920124[9]

Domain

15..65

PF09339 IclR helix-turn-helix domain

PMID:19920124[9]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=kdgR taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16129781

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:946129

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0006081

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P76268

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G7003

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG14018

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:946129

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120003590

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB3772

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 Murray, EL & Conway, T (2005) Multiple regulators control expression of the Entner-Doudoroff aldolase (Eda) of Escherichia coli. J. Bacteriol. 187 991-1000 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Pouyssegur, J & Stoeber, F (1974) Genetic control of the 2-keto-3-deoxy-d-gluconate metabolism in Escherichia coli K-12: kdg regulon. J. Bacteriol. 117 641-51 PubMed
  7. ↑ 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 7.12 7.13 7.14 7.15 7.16 7.17 7.18 7.19 7.20 7.21 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  8. ↑ 8.0 8.1 8.2 Macek, B et al. (2008) Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation. Mol. Cell Proteomics 7 299-307 PubMed
  9. ↑ 9.0 9.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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