ispA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

IspA

Synonyms

geranyltranstransferase[1], B0421[2][1], IspA[2][1] , ECK0415, JW0411, b0421

Product description

Farnesyl diphosphate synthase, isoprenoid biosynthesis[3]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000287

magnesium ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0460

F

Seeded from EcoCyc (v14.0)

complete

GO:0004337

geranyltranstransferase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.5.1.10

F

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0046872

metal ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

eutQ

PMID:15690043[4]

Experiment(s):EBI-889772

Protein

dnaK

PMID:15690043[4]

Experiment(s):EBI-889772

Protein

flxA

PMID:15690043[4]

Experiment(s):EBI-889772

Protein

purT

PMID:15690043[4]

Experiment(s):EBI-889772

Protein

rplC

PMID:15690043[4]

Experiment(s):EBI-889772

Protein

rplK

PMID:15690043[4]

Experiment(s):EBI-889772

Protein

rplL

PMID:15690043[4]

Experiment(s):EBI-889772

Protein

rplM

PMID:15690043[4]

Experiment(s):EBI-889772

Protein

rpsB

PMID:15690043[4]

Experiment(s):EBI-889772

Protein

rpsJ

PMID:15690043[4]

Experiment(s):EBI-889772

Protein

rpmG

PMID:15690043[4]

Experiment(s):EBI-889772

Protein

ydjX

PMID:16606699[5]

Experiment(s):EBI-1136547

Protein

rplB

PMID:16606699[5]

Experiment(s):EBI-1136547

Protein

yfiC

PMID:16606699[5]

Experiment(s):EBI-1136547

Protein

fliY

PMID:16606699[5]

Experiment(s):EBI-1136547

Protein

yafT

PMID:16606699[5]

Experiment(s):EBI-1136547

Protein

rplA

PMID:19402753[6]

MALDI(Z-score):30.479858

Protein

rpsD

PMID:19402753[6]

MALDI(Z-score):19.775499

Protein

rpsC

PMID:19402753[6]

MALDI(Z-score):33.397333

Protein

tufB

PMID:19402753[6]

MALDI(Z-score):22.733187

Protein

rho

PMID:19402753[6]

MALDI(Z-score):27.198092

Protein

flxA

PMID:19402753[6]

LCMS(ID Probability):99.0

Protein

purT

PMID:19402753[6]

LCMS(ID Probability):99.0

Protein

eutQ

PMID:19402753[6]

LCMS(ID Probability):99.0

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MDFPQQLEAC VKQANQALSR FIAPLPFQNT PVVETMQYGA LLGGKRLRPF LVYATGHMFG
VSTNTLDAPA AAVECIHAYS LIHDDLPAMD DDDLRRGLPT CHVKFGEANA ILAGDALQTL
AFSILSDADM PEVSDRDRIS MISELASASG IAGMCGGQAL DLDAEGKHVP LDALERIHRH
KTGALIRAAV RLGALSAGDK GRRALPVLDK YAESIGLAFQ VQDDILDVVG DTATLGKRQG
ADQQLGKSTY PALLGLEQAR KKARDLIDDA RQSLKQLAEQ SLDTSALEAL ADYIIQRNK
Length

299

Mol. Wt

32.16 kDa

pI

5.3 (calculated)

Extinction coefficient

8,940 - 9,440 (calc based on 6 Y, 0 W, and 4 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

32..295

PF00348 Polyprenyl synthetase

PMID:19920124[7]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=ispA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128406

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945064

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0001463

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P22939

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10508

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10508

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945064

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000501

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0503

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  4. ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  7. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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