holE:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

HolE

Synonyms

DNA polymerase III, theta subunit[1], B1842[2][1], HolE[2][1] , ECK1843, JW1831, b1842

Product description

DNA polymerase III, θ subunit[2][3];

Component of DNA polymerase III, core enzyme[3]; DNA polymerase III, holoenzyme[3]

DNA polymerase III, theta subunit[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003677

DNA binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009052

F

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011325

F

Seeded from EcoCyc (v14.0)

complete

GO:0003887

DNA-directed DNA polymerase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009052

F

Seeded from EcoCyc (v14.0)

complete

GO:0003887

DNA-directed DNA polymerase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011325

F

Seeded from EcoCyc (v14.0)

complete

GO:0003887

DNA-directed DNA polymerase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.7.7.7

F

Seeded from EcoCyc (v14.0)

complete

GO:0003887

DNA-directed DNA polymerase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0239

F

Seeded from EcoCyc (v14.0)

complete

GO:0006260

DNA replication

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009052

P

Seeded from EcoCyc (v14.0)

complete

GO:0006260

DNA replication

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011325

P

Seeded from EcoCyc (v14.0)

complete

GO:0006260

DNA replication

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0235

P

Seeded from EcoCyc (v14.0)

complete

GO:0016740

transferase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

Seeded from EcoCyc (v14.0)

complete

GO:0016779

nucleotidyltransferase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0548

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of DNA polymerase III, core enzyme

could be indirect

Protein

ssb

PMID:15690043[5]

Experiment(s):EBI-880105

Protein

dnaX

PMID:15690043[5]

Experiment(s):EBI-880105, EBI-885243, EBI-890677

Protein

holA

PMID:15690043[5]

Experiment(s):EBI-880105

Protein

holB

PMID:15690043[5]

Experiment(s):EBI-880105

Protein

holD

PMID:15690043[5]

Experiment(s):EBI-880105, EBI-885289

Protein

rplA

PMID:15690043[5]

Experiment(s):EBI-880105

Protein

rpsB

PMID:15690043[5]

Experiment(s):EBI-880105

Protein

rpsJ

PMID:15690043[5]

Experiment(s):EBI-880105

Protein

tufA

PMID:15690043[5]

Experiment(s):EBI-880105

Protein

dnaE

PMID:15690043[5]

Experiment(s):EBI-880105, EBI-885243, EBI-890781

Protein

dnaQ

PMID:15690043[5]

Experiment(s):EBI-880105, EBI-890575

Protein

dnaK

PMID:15690043[5]

Experiment(s):EBI-885243

Protein

hns

PMID:15690043[5]

Experiment(s):EBI-885243

Protein

katG

PMID:15690043[5]

Experiment(s):EBI-885243

Protein

rplL

PMID:15690043[5]

Experiment(s):EBI-885243

Protein

rplW

PMID:15690043[5]

Experiment(s):EBI-885243

Protein

rpsF

PMID:15690043[5]

Experiment(s):EBI-885243

Protein

rpsP

PMID:15690043[5]

Experiment(s):EBI-885243

Protein

topA

PMID:15690043[5]

Experiment(s):EBI-885243

Protein

ugpB

PMID:15690043[5]

Experiment(s):EBI-885243

Protein

yfiF

PMID:15690043[5]

Experiment(s):EBI-885243

Protein

pepD

PMID:16606699[6]

Experiment(s):EBI-1140965

Protein

ubiB

PMID:16606699[6]

Experiment(s):EBI-1140965

Protein

rpsA

PMID:16606699[6]

Experiment(s):EBI-1140965

Protein

nadE

PMID:16606699[6]

Experiment(s):EBI-1140965

Protein

dnaK

PMID:16606699[6]

Experiment(s):EBI-1140965

Protein

topA

PMID:19402753[7]

LCMS(ID Probability):99.0

Protein

tufB

PMID:19402753[7]

MALDI(Z-score):18.861140

Protein

ugpB

PMID:19402753[7]

LCMS(ID Probability):99.0

Protein

holA

PMID:19402753[7]

MALDI(Z-score):34.206923

Protein

ssb

PMID:19402753[7]

LCMS(ID Probability):86.1 MALDI(Z-score):29.286580

Protein

dnaX

PMID:19402753[7]

LCMS(ID Probability):99.2 MALDI(Z-score):29.086083

Protein

holB

PMID:19402753[7]

MALDI(Z-score):35.542904

Protein

rplL

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

Subunits of DNA polymerase III, holoenzyme

could be indirect


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

cytoplasm

From EcoCyc[3]


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MLKNLAKLDQ TEMDKVNVDL AAAGVAFKER YNMPVIAEAV EREQPEHLRS WFRERLIAHR
LASVNLSRLP YEPKLK
Length

76

Mol. Wt

8.846 kDa

pI

9.5 (calculated)

Extinction coefficient

8,480 (calc based on 2 Y, 1 W, and 0 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

1..75

PF06440 DNA polymerase III, theta subunit

PMID:19920124[8]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=holE taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16129795

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947471

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0006126

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0ABS8

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11505

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11505

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947471

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001461

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1468

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 5.12 5.13 5.14 5.15 5.16 5.17 5.18 5.19 5.20 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 6.4 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  8. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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