hemH:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

HemH

Synonyms

ferrochelatase[1], B0475[2][1], VisA[2][1], PopA[2][1], HemH[2][1] , ECK0469, JW0464, popA, visA, b0475

Product description

PROTOHEME- Ferrochelatase[3]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004325

ferrochelatase activity

PMID:1397280[4]

IMP: Inferred from Mutant Phenotype

F

complete

GO:0004325

ferrochelatase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00323

F

Seeded from EcoCyc (v14.0)

complete

GO:0004325

ferrochelatase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001015

F

Seeded from EcoCyc (v14.0)

complete

GO:0009416

response to light stimulus

PMID:2051480[5]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0004325

ferrochelatase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR019772

F

Seeded from EcoCyc (v14.0)

complete

GO:0004325

ferrochelatase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:4.99.1.1

F

Seeded from EcoCyc (v14.0)

complete

GO:0004325

ferrochelatase activity

PMID:8458858[6]

IMP: Inferred from Mutant Phenotype

F

complete

GO:0005506

iron ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0408

F

Seeded from EcoCyc (v14.0)

complete

GO:0004325

ferrochelatase activity

PMID:8458858[6]

IDA: Inferred from Direct Assay

F

complete

GO:0005737

cytoplasm

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00323

C

Seeded from EcoCyc (v14.0)

complete

GO:0006783

heme biosynthetic process

PMID:8458858[6]

IDA: Inferred from Direct Assay

P

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0009416

response to light stimulus

PMID:1835790[7]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0006783

heme biosynthetic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00323

P

Seeded from EcoCyc (v14.0)

complete

GO:0006783

heme biosynthetic process

PMID:1835790[7]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0046501

protoporphyrinogen IX metabolic process

PMID:1397280[4]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0006783

heme biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001015

P

Seeded from EcoCyc (v14.0)

complete

GO:0006783

heme biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR019772

P

Seeded from EcoCyc (v14.0)

complete

GO:0006783

heme biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0350

P

Seeded from EcoCyc (v14.0)

complete

GO:0046872

metal ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

rplA

PMID:16606699[8]

Experiment(s):EBI-1136808

Protein

hchA

PMID:16606699[8]

Experiment(s):EBI-1136808

Protein

asnA

PMID:16606699[8]

Experiment(s):EBI-1136808

Protein

sdhA

PMID:16606699[8]

Experiment(s):EBI-1136808

Protein

htpG

PMID:16606699[8]

Experiment(s):EBI-1136808

Protein

kdpB

PMID:16606699[8]

Experiment(s):EBI-1136808

Protein

glpD

PMID:16606699[8]

Experiment(s):EBI-1136808

Protein

dadA

PMID:16606699[8]

Experiment(s):EBI-1136808
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MRQTKTGILL ANLGTPDAPT PEAVKRYLKQ FLSDRRVVDT SRLLWWPLLR GVILPLRSPR
VAKLYASVWM EGGSPLMVYS RQQQQALAQR LPEMPVALGM SYGSPSLESA VDELLAEHVD
HIVVLPLYPQ FSCSTVGAVW DELARILARK RSIPGISFIR DYADNHDYIN ALANSVRASF
AKHGEPDLLL LSYHGIPQRY ADEGDDYPQR CRTTTRELAS ALGMAPEKVM MTFQSRFGRE
PWLMPYTDET LKMLGEKGVG HIQVMCPGFA ADCLETLEEI AEQNREVFLG AGGKKYEYIP
ALNATPEHIE MMANLVAAYR
Length

320

Mol. Wt

35.884 kDa

pI

6.6 (calculated)

Extinction coefficient

48,360 - 48,860 (calc based on 14 Y, 5 W, and 4 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

5..320

PF00762 Ferrochelatase

PMID:19920124[9]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=hemH taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128459

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947532

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0001649

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P23871

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10431

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10431

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947532

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000424

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0426

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  4. ↑ 4.0 4.1 Miyamoto, K et al. (1992) Accumulation of protoporphyrin IX in light-sensitive mutants of Escherichia coli. FEBS Lett. 310 246-8 PubMed
  5. ↑ Miyamoto, K et al. (1991) Isolation and characterization of visible light-sensitive mutants of Escherichia coli K12. J. Mol. Biol. 219 393-8 PubMed
  6. ↑ 6.0 6.1 6.2 Frustaci, JM & O'Brian, MR (1993) The Escherichia coli visA gene encodes ferrochelatase, the final enzyme of the heme biosynthetic pathway. J. Bacteriol. 175 2154-6 PubMed
  7. ↑ 7.0 7.1 Nakahigashi, K et al. (1991) Photosensitivity of a protoporphyrin-accumulating, light-sensitive mutant (visA) of Escherichia coli K-12. Proc. Natl. Acad. Sci. U.S.A. 88 10520-4 PubMed
  8. ↑ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 8.7 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  9. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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