helD:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

HelD

Synonyms

DNA helicase IV[1], B0962[2][1], SrjB[2][1], HelD[2][1] , ECK0953, JW0945, srjB, b0962

Product description

DNA helicase IV[2][3]

ATP-dependent DNA Helicase IV[4]

EC number (for enzymes)

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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000155

two-component sensor activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003661

F

Seeded from EcoCyc (v14.0)

complete

GO:0006261

DNA-dependent DNA replication

P

Seeded from Riley et al 2006 [1].

Missing: evidence, reference

GO:0000166

nucleotide binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000212

F

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

Seeded from EcoCyc (v14.0)

complete

GO:0004003

ATP-dependent DNA helicase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000212

F

Seeded from EcoCyc (v14.0)

complete

GO:0004386

helicase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0347

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000212

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014016

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

Seeded from EcoCyc (v14.0)

complete

GO:0006281

DNA repair

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000212

P

Seeded from EcoCyc (v14.0)

complete

GO:0007165

signal transduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003661

P

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003661

C

Seeded from EcoCyc (v14.0)

complete

GO:0016787

hydrolase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014016

F

Seeded from EcoCyc (v14.0)

complete

GO:0016787

hydrolase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0378

F

Seeded from EcoCyc (v14.0)

complete

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

tufA

PMID:15690043[5]

Experiment(s):EBI-880994, EBI-887624

Protein

accB

PMID:15690043[5]

Experiment(s):EBI-887624

Protein

atpD

PMID:15690043[5]

Experiment(s):EBI-887624

Protein

csrA

PMID:15690043[5]

Experiment(s):EBI-887624

Protein

dnaK

PMID:15690043[5]

Experiment(s):EBI-887624

Protein

gadB

PMID:15690043[5]

Experiment(s):EBI-887624

Protein

gcvP

PMID:15690043[5]

Experiment(s):EBI-887624

Protein

infB

PMID:15690043[5]

Experiment(s):EBI-887624

Protein

lipA

PMID:15690043[5]

Experiment(s):EBI-887624

Protein

groL

PMID:15690043[5]

Experiment(s):EBI-887624

Protein

pflB

PMID:15690043[5]

Experiment(s):EBI-887624

Protein

pgk

PMID:15690043[5]

Experiment(s):EBI-887624

Protein

ptsI

PMID:15690043[5]

Experiment(s):EBI-887624

Protein

rplC

PMID:15690043[5]

Experiment(s):EBI-887624

Protein

rplD

PMID:15690043[5]

Experiment(s):EBI-887624

Protein

rplL

PMID:15690043[5]

Experiment(s):EBI-887624

Protein

rplU

PMID:15690043[5]

Experiment(s):EBI-887624

Protein

rpsA

PMID:15690043[5]

Experiment(s):EBI-887624

Protein

rpsG

PMID:15690043[5]

Experiment(s):EBI-887624

Protein

tpiA

PMID:15690043[5]

Experiment(s):EBI-887624

Protein

gapA

PMID:15690043[5]

Experiment(s):EBI-887624

Protein

dnaK

PMID:16606699[6]

Experiment(s):EBI-1138489

Protein

groL

PMID:16606699[6]

Experiment(s):EBI-1138489

Protein

gapA

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

gadB

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

pgk

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

infB

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

atpD

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

groL

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

gcvP

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

tufB

PMID:19402753[7]

MALDI(Z-score):19.099796

Protein

rplU

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

groS

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rpsA

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

accB

PMID:19402753[7]

LCMS(ID Probability):99.3

Protein

pflB

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

tpiA

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rplD

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

csrA

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

lipA

PMID:19402753[7]

LCMS(ID Probability):99.3

Protein

ptsI

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rplL

PMID:19402753[7]

LCMS(ID Probability):99.6

</protect>

Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

<protect></protect>

Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc

MELKATTLGK RLAQHPYDRA VILNAGIKVS GDRHEYLIPF NQLLAIHCKR GLVWGELEFV
LPDEKVVRLH GTEWGETQRF YHHLDAHWRR WSGEMSEIAS GVLRQQLDLI ATRTGENKWL
TREQTSGVQQ QIRQALSALP LPVNRLEEFD NCREAWRKCQ AWLKDIESAR LQHNQAYTEA
MLTEYADFFR QVESSPLNPA QARAVVNGEH SLLVLAGAGS GKTSVLVARA GWLLARGEAS
PEQILLLAFG RKAAEEMDER IRERLHTEDI TARTFHALAL HIIQQGSKKV PIVSKLENDT
AARHELFIAE WRKQCSEKKA QAKGWRQWLT EEMQWSVPEG NFWDDEKLQR RLASRLDRWV
SLMRMHGGAQ AEMIASAPEE IRDLFSKRIK LMAPLLKAWK GALKAENAVD FSGLIHQAIV
ILEKGRFISP WKHILVDEFQ DISPQRAALL AALRKQNSQT TLFAVGDDWQ AIYRFSGAQM
SLTTAFHENF GEGERCDLDT TYRFNSRIGE VANRFIQQNP GQLKKPLNSL TNGDKKAVTL
LDESQLDALL DKLSGYAKPE ERILILARYH HMRPASLEKA ATRWPKLQID FMTIHASKGQ
QADYVIIVGL QEGSDGFPAA ARESIMEEAL LPPVEDFPDA EERRLMYVAL TRARHRVWAL
FNKENPSPFV EILKNLDVPV ARKP
Length

684

Mol. Wt

77.977 kDa

pI

8.5 (calculated)

Extinction coefficient

120,890 - 121,515 (calc based on 11 Y, 19 W, and 5 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

197..600

PF00580 UvrD/REP helicase

PMID:19920124[8]

Domain

1..165

PF12462 DNA helicase IV / RNA helicase N terminal

PMID:19920124[8]

<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=helD taxon=562,83333 </beststructure>

Models

View models at:

</protect>

Structure figures

<protect>

</protect>

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference

<protect></protect>

Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128929

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:946227

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0003257

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P15038

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10426

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10426

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:946227

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000419

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0421

Escherichia coli str. K-12 substr. MG1655

<protect></protect>

Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 5.12 5.13 5.14 5.15 5.16 5.17 5.18 5.19 5.20 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  6. 6.0 6.1 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  7. 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 7.12 7.13 7.14 7.15 7.16 7.17 7.18 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  8. 8.0 8.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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