hcaR:Gene Product(s)

From EcoliWiki
Jump to: navigation, search

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

HcaR

Synonyms

DNA-binding transcriptional activator of 3-phenylpropionic acid catabolism[1], B2537[2][1], PhdR[2][1], HcaR[2][1], YfhT[2][1] , ECK2534, JW2521, phdR, yfhT, b2537

Product description

HcaR transcriptional dual regulator[2][3]

Transcriptional activator of the hca operon; inducd by 3-phenylpropionate and cinnamic acid; autoregulatory[4]

EC number (for enzymes)


edit table

<protect></protect>

Notes

Function

[back to top]


<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003700

transcription factor activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000847

F

Seeded from EcoCyc (v14.0)

complete

GO:0003700

transcription factor activity

PMID:11200225[5]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0003700

transcription factor activity

PMID:9603882[6]

ISS: Inferred from Sequence or Structural Similarity

GB:M33817
GB:M76991
GB:L04470
GB:D90801
GB:D38633
GB:M98445
GB:M80212
GB:L06464
GB:AE16782
GB:U32867
GB:J04233

F

Seeded from EcoCyc (v14.0)

complete

GO:0016563

transcription activator activity

PMID:11200225[5]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0016563

transcription activator activity

PMID:9603882[6]

ISS: Inferred from Sequence or Structural Similarity

GB:M33817
GB:M76991
GB:L04470
GB:D90801
GB:D38633
GB:M98445
GB:M80212
GB:L06464
GB:AE16782
GB:U32867
GB:J04233

F

Seeded from EcoCyc (v14.0)

complete

GO:0016566

specific transcriptional repressor activity

PMID:11200225[5]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

PMID:15808934[7]

IDA: Inferred from Direct Assay

F

complete

GO:0016566

specific transcriptional repressor activity

PMID:9603882[6]

ISS: Inferred from Sequence or Structural Similarity

GB:M33817
GB:M76991
GB:L04470
GB:D90801
GB:D38633
GB:M98445
GB:M80212
GB:L06464
GB:AE16782
GB:U32867
GB:J04233

F

Seeded from EcoCyc (v14.0)

complete

GO:0032582

negative regulation of gene-specific transcription

PMID:11200225[5]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc (v14.0)

complete

GO:0032582

negative regulation of gene-specific transcription

PMID:9603882[6]

ISS: Inferred from Sequence or Structural Similarity

GB:M33817
GB:M76991
GB:L04470
GB:D90801
GB:D38633
GB:M98445
GB:M80212
GB:L06464
GB:AE16782
GB:U32867
GB:J04233

P

Seeded from EcoCyc (v14.0)

complete

GO:0043193

positive regulation of gene-specific transcription

PMID:11200225[5]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc (v14.0)

complete

GO:0043193

positive regulation of gene-specific transcription

PMID:9603882[6]

ISS: Inferred from Sequence or Structural Similarity

GB:M33817
GB:M76991
GB:L04470
GB:D90801
GB:D38633
GB:M98445
GB:M80212
GB:L06464
GB:AE16782
GB:U32867
GB:J04233

P

Seeded from EcoCyc (v14.0)

complete

edit table

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

groL

PMID:16606699[8]

Experiment(s):EBI-1143188

Protein

rfaC

PMID:16606699[8]

Experiment(s):EBI-1143188
edit table

</protect>

Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
edit table

<protect></protect>

Notes

Structure and Physical Properties

[back to top]


<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MELRHLRYFV AVAQALNFTR AAEKLHTSQP SLSSQIRDLE NCVGVPLLVR DKRKVALTAA
GECFLQDALA ILEQAENAKL RARKIVQEDR QLTIGFVPSA EVNLLPKVLP MFRLRQPDTL
IELVSLITTQ QEEKIRRGEL DVGLMRHPVY SPEIDYLELF DEPLVVVLPV DHPLAHEKEI
TAAQLDGVNF VSTDPVYSGS LAPIVKAWFA QENSQPNIVQ VATNILVTMN LVGMGLGVTL
IPGYMNNFNT GQVVFRPIAG NVPSIALLMA WKKGEMKPAL RDFIAIVQER LASVTA
Length

296

Mol. Wt

32.838 kDa

pI

6.4 (calculated)

Extinction coefficient

18,450 - 18,700 (calc based on 5 Y, 2 W, and 2 C residues)

edit table


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

86..292

PF03466 LysR substrate binding domain

PMID:19920124[9]

Domain

3..62

PF00126 Bacterial regulatory helix-turn-helix protein, lysR family

PMID:19920124[9]

edit table

<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=hcaR taxon=562,83333 </beststructure>

Models

View models at:

edit table
</protect>

Structure figures

<protect>

</protect>

Notes

Gene Product Resources

[back to top]


See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
edit table

<protect></protect>

Notes

Accessions in Other Databases

[back to top]


See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16130462

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947000

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0008351

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:Q47141

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G7331

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG13455

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947000

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120003903

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB3228

Escherichia coli str. K-12 substr. MG1655

edit table

<protect></protect>

Notes

Links

[back to top]




References

[back to top]


See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Turlin, E et al. (2001) Regulation of the early steps of 3-phenylpropionate catabolism in Escherichia coli. J. Mol. Microbiol. Biotechnol. 3 127-33 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 6.4 Díaz, E et al. (1998) Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12. J. Bacteriol. 180 2915-23 PubMed
  7. ↑ Turlin, E et al. (2005) 3-phenylpropionate catabolism and the Escherichia coli oxidative stress response. Res. Microbiol. 156 312-21 PubMed
  8. ↑ 8.0 8.1 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  9. ↑ 9.0 9.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

[back to top]


Retrieved from "https://ecoliwiki.org/colipedia/index.php?title=hcaR:Gene_Product(s)&oldid=1494409"