gmr:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

Gmr

Synonyms

modulator of Rnase II stability[1], Gmr[2][1], YciR[2][1], B1285[2][1] , ECK1280, JW1278, yciR, b1285

Product description

modulator of RNase II stability[2][3]

Cyclic-di-GMP phosphodiesterase, csgD regulator; modulates protein stability of RNase II[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004871

signal transducer activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000014

F

Seeded from EcoCyc (v14.0)

complete

GO:0006355

regulation of transcription, DNA-dependent

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013767

P

Seeded from EcoCyc (v14.0)

complete

GO:0007165

signal transduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000014

P

Seeded from EcoCyc (v14.0)

complete

GO:0010608

posttranscriptional regulation of gene expression

PMID:11260472[5]

IMP: Inferred from Mutant Phenotype

P

Seeded from EcoCyc (v14.0)

complete

GO:0071111

cyclic-guanylate-specific phosphodiesterase activity

PMID:17010156[6]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

sdhA

PMID:16606699[7]

Experiment(s):EBI-1139471

Protein

groL

PMID:16606699[7]

Experiment(s):EBI-1139471

Protein

tldD

PMID:19402753[8]

LCMS(ID Probability):99.6 MALDI(Z-score):28.121030

Protein

ydfU

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

argR

PMID:19402753[8]

LCMS(ID Probability):99.4

Protein

pmbA

PMID:19402753[8]

LCMS(ID Probability):99.6 MALDI(Z-score):39.822271

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc

MKTVRESTTL YNFLGSHNPY WRLTESSDVL RFSTTETTEP DRTLQLSAEQ AARIREMTVI
TSSLMMSLTV DESDLSVHLV GRKINKREWA GNASAWHDTP AVARDLSHGL SFAEQVVSEA
HSAIVILDSR GNIQRFNRLC EDYTGLKEHD VIGQSVFKLF MSRREAAASR RNNRVFFRSG
NAYEVELWIP TCKGQRLFLF RNKFVHSGSG KNEIFLICSG TDITEERRAQ ERLRILANTD
SITGLPNRNA MQDLIDHAIN HADNNKVGVV YLDLDNFKKV NDAYGHLFGD QLLRDVSLAI
LSCLEHDQVL ARPGGDEFLV LASNTSQSAL EAMASRILTR LRLPFRIGLI EVYTSCSVGI
ALSPEHGSDS TAIIRHADTA MYTAKEGGRG QFCVFTPEMN QRVFEYLWLD TNLRKALEND
QLVIHYQPKI TWRGEVRSLE ALVRWQSPER GLIPPLDFIS YAEESGLIVP LGRWVILDVV
RQVAKWRDKG INLRVAVNIS ARQLADQTIF TALKQVLQEL NFEYCPIDVE LTESCLIEND
ELALSVIQQF SQLGAQVHLD DFGTGYSSLS QLARFPIDAI KLDQVFVRDI HKQPVSQSLV
RAIVAVAQAL NLQVIAEGVE SAKEDAFLTK NGINERQGFL FAKPMPAVAF ERWYKRYLKR A
Length

661

Mol. Wt

74.665 kDa

pI

6.8 (calculated)

Extinction coefficient

77,350 - 78,350 (calc based on 15 Y, 10 W, and 8 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

237..391

PF00990 GGDEF domain

PMID:19920124[9]

Domain

410..644

PF00563 EAL domain

PMID:19920124[9]

Domain

111..223

PF00989 PAS fold

PMID:19920124[9]

<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=gmr taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16129246

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945868

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0004317

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P77334

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G6639

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG13415

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945868

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120003234

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB3191

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. Cairrão, F et al. (2001) RNase II levels change according to the growth conditions: characterization of gmr, a new Escherichia coli gene involved in the modulation of RNase II. Mol. Microbiol. 39 1550-61 PubMed
  6. Weber, H et al. (2006) Cyclic-di-GMP-mediated signalling within the sigma network of Escherichia coli. Mol. Microbiol. 62 1014-34 PubMed
  7. 7.0 7.1 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  8. 8.0 8.1 8.2 8.3 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  9. 9.0 9.1 9.2 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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