fixA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

FixA

Synonyms

predicted electron transfer flavoprotein subunit, ETFP adenine nucleotide-binding domain[1], B0041[2][1], YaaQ[2][1], FixA[2][1] , ECK0042, JW0040, yaaQ, b0041

Product description

probable flavoprotein subunit required for anaerobic carnitine metabolism[2][3]

Required for anaerobic carnitine reduction; similar to Rhizobium fix gene[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0006810

transport

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0813

P

Seeded from EcoCyc (v14.0)

complete

GO:0009055

electron carrier activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000049

F

Seeded from EcoCyc (v14.0)

complete

GO:0009055

electron carrier activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012255

F

Seeded from EcoCyc (v14.0)

complete

GO:0009437

carnitine metabolic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01055

P

Seeded from EcoCyc (v14.0)

complete

GO:0022900

electron transport chain

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0249

P

Seeded from EcoCyc (v14.0)

complete

GO:0009437

carnitine metabolic process

PMID:12081978[5]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0055114

oxidation reduction

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01055

P

Seeded from EcoCyc (v14.0)

complete

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

dnaK

PMID:16606699[6]

Experiment(s):EBI-1135409

Protein

ulaF

PMID:16606699[6]

Experiment(s):EBI-1135409

Protein

nadE

PMID:16606699[6]

Experiment(s):EBI-1135409

Protein

ttdA

PMID:16606699[6]

Experiment(s):EBI-1135409

Protein

rpsC

PMID:16606699[6]

Experiment(s):EBI-1135409

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc

MNDVSFMISG DAMKIITCYK CVPDEQDIAV NNADGSLDFS KADAKISQYD LNAIEAACQL
KQQAAEAQVT ALSVGGKALT NAKGRKDVLS RGPDELIVVI DDQFEQALPQ QTASALAAAA
QKAGFDLILC GDGSSDLYAQ QVGLLVGEIL NIPAVNGVSK IISLTADTLT VERELEDETE
TLSIPLPAVV AVSTDINSPQ IPSMKAILGA AKKPVQVWSA ADIGFNAEAA WSEQQVAAPK
QRERQRIVIE GDGEEQIAAF AENLRKVI
Length

268

Mol. Wt

28.412 kDa

pI

4.2 (calculated)

Extinction coefficient

15,470 - 15,970 (calc based on 3 Y, 2 W, and 4 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

24..187

PF01012 Electron transfer flavoprotein domain

PMID:19920124[7]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=fixA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:90111081

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0000145

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P60566

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11562

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11562

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947316

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001515

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947316

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1523

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. Walt, A & Kahn, ML (2002) The fixA and fixB genes are necessary for anaerobic carnitine reduction in Escherichia coli. J. Bacteriol. 184 4044-7 PubMed
  6. 6.0 6.1 6.2 6.3 6.4 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  7. Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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