dsbA:Gene Product(s)

From EcoliWiki
Jump to: navigation, search

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

DsbA

Synonyms

periplasmic protein disulfide isomerase I[1], B3860[2][1], Dsf[2][1], PpfA[2][1], IarA[2][1], DsbA[2][1] , dsf, ECK3852, iarA, JW3832, ppfA, b3860

Product description

Thiol:disulfide interchange protein, periplasmic; alkali-inducible[3]

EC number (for enzymes)
edit table

<protect></protect>

Notes

Function

[back to top]


<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005515

protein binding

PMID:16606699[4]

IPI: Inferred from Physical Interaction

UniProtKB:P0A7V0

F

Seeded from EcoCyc (v14.0)

complete

GO:0003756

protein disulfide isomerase activity

PMID:1934062[5]

IDA: Inferred from Direct Assay

F

act to reduce insulin disulfide bonds in vitro

complete

GO:0005515

protein binding

PMID:17110337[6]

IPI: Inferred from Physical Interaction

UniProtKB:P0A6M2

F

Seeded from EcoCyc (v14.0)

complete

GO:0006457

protein folding

PMID:1934062[5]

IMP: Inferred from Mutant Phenotype

P

Seeded from EcoCyc (v14.0)

complete

GO:0015035

protein disulfide oxidoreductase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001853

F

Seeded from EcoCyc (v14.0)

complete

GO:0015035

protein disulfide oxidoreductase activity

PMID:1934062[5]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0030288

outer membrane-bounded periplasmic space

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001853

C

Seeded from EcoCyc (v14.0)

complete

GO:0030288

outer membrane-bounded periplasmic space

PMID:1934062[5]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0015035

protein disulfide oxidoreductase activity

PMID:7487336[7]

IMP: Inferred from Mutant Phenotype

F

complete

GO:0071236

cellular response to antibiotic

PMID:7628442[8]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0045454

cell redox homeostasis

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017936

P

Seeded from EcoCyc (v14.0)

complete

GO:0045454

cell redox homeostasis

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017937

P

Seeded from EcoCyc (v14.0)

complete

edit table

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

acnA

PMID:15690043[9]

Experiment(s):EBI-893379

Protein

kbaY

PMID:15690043[9]

Experiment(s):EBI-893379

Protein

insE1

PMID:15690043[9]

Experiment(s):EBI-893379

Protein

dctA

PMID:15690043[9]

Experiment(s):EBI-893379

Protein

dsbC

PMID:15690043[9]

Experiment(s):EBI-893379

Protein

fliA

PMID:15690043[9]

Experiment(s):EBI-893379

Protein

hybC

PMID:15690043[9]

Experiment(s):EBI-893379

Protein

katE

PMID:15690043[9]

Experiment(s):EBI-893379

Protein

mltB

PMID:15690043[9]

Experiment(s):EBI-893379

Protein

tap

PMID:15690043[9]

Experiment(s):EBI-893379

Protein

ydhU

PMID:15690043[9]

Experiment(s):EBI-893379

Protein

gfcC

PMID:15690043[9]

Experiment(s):EBI-893379

Protein

ymfN

PMID:15690043[9]

Experiment(s):EBI-893379

Protein

rpsB

PMID:16606699[4]

Experiment(s):EBI-1146823

Protein

acnA

PMID:19402753[10]

LCMS(ID Probability):99.0

Protein

hybC

PMID:19402753[10]

LCMS(ID Probability):99.0

Protein

ydhU

PMID:19402753[10]

LCMS(ID Probability):99.0

Protein

katE

PMID:19402753[10]

LCMS(ID Probability):99.0

Protein

mltB

PMID:19402753[10]

LCMS(ID Probability):99.0

Protein

gfcC

PMID:19402753[10]

LCMS(ID Probability):99.0

Protein

kbaY

PMID:19402753[10]

LCMS(ID Probability):99.0

Protein

fliA

PMID:19402753[10]

LCMS(ID Probability):99.0

Protein

dsbC

PMID:19402753[10]

LCMS(ID Probability):99.0

Protein

tap

PMID:19402753[10]

LCMS(ID Probability):99.0

Protein

dctA

PMID:19402753[10]

LCMS(ID Probability):99.0

edit table

</protect>

Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

Periplasm

PMID:9298646[11]

EchoLocation:dsbA

periplasm

From EcoCyc[12]


edit table

<protect></protect>

Notes

Structure and Physical Properties

[back to top]


<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MKKIWLALAG LVLAFSASAA QYEDGKQYTT LEKPVAGAPQ VLEFFSFFCP HCYQFEEVLH
ISDNVKKKLP EGVKMTKYHV NFMGGDLGKD LTQAWAVAMA LGVEDKVTVP LFEGVQKTQT
IRSASDIRDV FINAGIKGEE YDAAWNSFVV KSLVAQQEKA AADVQLRGVP AMFVNGKYQL
NPQGMDTSNM DVFVQQYADT VKYLSEKK
Length

208

Mol. Wt

23.103 kDa

pI

6.3 (calculated)

Extinction coefficient

28,420 - 28,670 (calc based on 8 Y, 3 W, and 2 C residues)

edit table


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

motif

1-19

UniProt Manual:Signal Peptides

UniProt:P0AEG4

Domain

40..198

PF01323 DSBA-like thioredoxin domain

PMID:19920124[13]

edit table

<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=dsbA taxon=562,83333 </beststructure>

Models

View models at:

edit table
</protect>

Structure figures

<protect>

</protect>

Notes

Gene Product Resources

[back to top]


See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
edit table

<protect></protect>

Notes

Accessions in Other Databases

[back to top]


See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16131701

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948353

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0012606

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0AEG4

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11297

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11297

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948353

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001270

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1274

Escherichia coli str. K-12 substr. MG1655

edit table

<protect></protect>

Notes

Links

[back to top]




References

[back to top]


See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  4. ↑ 4.0 4.1 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  5. ↑ 5.0 5.1 5.2 5.3 Bardwell, JC et al. (1991) Identification of a protein required for disulfide bond formation in vivo. Cell 67 581-9 PubMed
  6. ↑ Inaba, K et al. (2006) Crystal structure of the DsbB-DsbA complex reveals a mechanism of disulfide bond generation. Cell 127 789-801 PubMed
  7. ↑ Metheringham, R et al. (1995) An essential role for DsbA in cytochrome c synthesis and formate-dependent nitrite reduction by Escherichia coli K-12. Arch. Microbiol. 164 301-7 PubMed
  8. ↑ Missiakas, D et al. (1995) Identification and characterization of a new disulfide isomerase-like protein (DsbD) in Escherichia coli. EMBO J. 14 3415-24 PubMed
  9. ↑ 9.00 9.01 9.02 9.03 9.04 9.05 9.06 9.07 9.08 9.09 9.10 9.11 9.12 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  10. ↑ 10.00 10.01 10.02 10.03 10.04 10.05 10.06 10.07 10.08 10.09 10.10 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  11. ↑ Link, AJ et al. (1997) Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12. Electrophoresis 18 1259-313 PubMed
  12. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  13. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

[back to top]


Retrieved from "https://ecoliwiki.org/colipedia/index.php?title=dsbA:Gene_Product(s)&oldid=1495620"