dnaQ:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

DnaQ

Synonyms

DNA polymerase III epsilon subunit[1], B0215[2][1], MutD[2][1], DnaQ[2][1] , ECK0215, JW0205, mutD, b0215

Product description

DNA polymerase III, ε subunit[2][3];

Component of DNA polymerase III, core enzyme[3]; DNA polymerase III, holoenzyme[3]

DNA polymerase III epsilon subunit; streptomycin, azaserine resistant; 3' to 5' proofreading, lexA regulon[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000287

magnesium ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0460

F

Seeded from EcoCyc (v14.0)

complete

GO:0003676

nucleic acid binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012337

F

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006054

F

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006309

F

Seeded from EcoCyc (v14.0)

complete

GO:0003887

DNA-directed DNA polymerase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006054

F

Seeded from EcoCyc (v14.0)

complete

GO:0003887

DNA-directed DNA polymerase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006309

F

Seeded from EcoCyc (v14.0)

complete

GO:0003887

DNA-directed DNA polymerase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.7.7.7

F

Seeded from EcoCyc (v14.0)

complete

GO:0003887

DNA-directed DNA polymerase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0239

F

Seeded from EcoCyc (v14.0)

complete

GO:0004518

nuclease activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0540

F

Seeded from EcoCyc (v14.0)

complete

GO:0004527

exonuclease activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006055

F

Seeded from EcoCyc (v14.0)

complete

GO:0004527

exonuclease activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0269

F

Seeded from EcoCyc (v14.0)

complete

GO:0005622

intracellular

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006055

C

Seeded from EcoCyc (v14.0)

complete

GO:0006260

DNA replication

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006054

P

Seeded from EcoCyc (v14.0)

complete

GO:0006260

DNA replication

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006309

P

Seeded from EcoCyc (v14.0)

complete

GO:0006260

DNA replication

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0235

P

Seeded from EcoCyc (v14.0)

complete

GO:0016740

transferase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

Seeded from EcoCyc (v14.0)

complete

GO:0016779

nucleotidyltransferase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0548

F

Seeded from EcoCyc (v14.0)

complete

GO:0016787

hydrolase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0378

F

Seeded from EcoCyc (v14.0)

complete

GO:0030145

manganese ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0464

F

Seeded from EcoCyc (v14.0)

complete

GO:0046872

metal ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of DNA polymerase III, core enzyme

could be indirect

Protein

ssb

PMID:15690043[5]

Experiment(s):EBI-883264

Protein

dnaE

PMID:15690043[5]

Experiment(s):EBI-883264, EBI-883487, EBI-890575, EBI-890781

Protein

dnaX

PMID:15690043[5]

Experiment(s):EBI-883264, EBI-890575, EBI-890677

Protein

holA

PMID:15690043[5]

Experiment(s):EBI-883264

Protein

holB

PMID:15690043[5]

Experiment(s):EBI-883264, EBI-890575

Protein

holC

PMID:15690043[5]

Experiment(s):EBI-883264, EBI-880166, EBI-885330, EBI-890575

Protein

holD

PMID:15690043[5]

Experiment(s):EBI-883264, EBI-880133, EBI-890575

Protein

rplA

PMID:15690043[5]

Experiment(s):EBI-883264, EBI-890575

Protein

tufA

PMID:15690043[5]

Experiment(s):EBI-883264

Protein

yciK

PMID:16606699[6]

Experiment(s):EBI-1135945

Protein

napC

PMID:16606699[6]

Experiment(s):EBI-1135945

Protein

slyD

PMID:16606699[6]

Experiment(s):EBI-1135945

Protein

atpB

PMID:15690043[5]

Experiment(s):EBI-890575

Protein

cspC

PMID:15690043[5]

Experiment(s):EBI-890575

Protein

fecB

PMID:15690043[5]

Experiment(s):EBI-890575

Protein

lon

PMID:15690043[5]

Experiment(s):EBI-890575

Protein

nusG

PMID:15690043[5]

Experiment(s):EBI-890575

Protein

rplL

PMID:15690043[5]

Experiment(s):EBI-890575

Protein

rplM

PMID:15690043[5]

Experiment(s):EBI-890575

Protein

rplS

PMID:15690043[5]

Experiment(s):EBI-890575

Protein

rpmC

PMID:15690043[5]

Experiment(s):EBI-890575

Protein

rpmG

PMID:15690043[5]

Experiment(s):EBI-890575

Protein

slyD

PMID:15690043[5]

Experiment(s):EBI-890575

Protein

yfiF

PMID:15690043[5]

Experiment(s):EBI-890575

Protein

ydiH

PMID:15690043[5]

Experiment(s):EBI-890575

Protein

rpmG

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

tufB

PMID:19402753[7]

MALDI(Z-score):21.928144

Protein

rplA

PMID:19402753[7]

LCMS(ID Probability):99.0 MALDI(Z-score):17.053160

Protein

holA

PMID:19402753[7]

MALDI(Z-score):38.028436

Protein

ssb

PMID:19402753[7]

MALDI(Z-score):33.961415

Protein

holB

PMID:19402753[7]

LCMS(ID Probability):99.0 MALDI(Z-score):36.837342

Protein

holE

PMID:19402753[7]

LCMS(ID Probability):99.6 MALDI(Z-score):38.098428

Protein

holD

PMID:19402753[7]

LCMS(ID Probability):99.0 MALDI(Z-score):27.315717

Protein

dnaX

PMID:19402753[7]

LCMS(ID Probability):99.0 MALDI(Z-score):28.496617

Protein

atpB

PMID:19402753[7]

LCMS(ID Probability):99.0

Protein

fecB

PMID:19402753[7]

LCMS(ID Probability):99.0

Protein

rplL

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

Subunits of DNA polymerase III, holoenzyme

could be indirect


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MSTAITRQIV LDTETTGMNQ IGAHYEGHKI IEIGAVEVVN RRLTGNNFHV YLKPDRLVDP
EAFGVHGIAD EFLLDKPTFA EVADEFMDYI RGAELVIHNA AFDIGFMDYE FSLLKRDIPK
TNTFCKVTDS LAVARKMFPG KRNSLDALCA RYEIDNSKRT LHGALLDAQI LAEVYLAMTG
GQTSMAFAME GETQQQQGEA TIQRIVRQAS KLRVVFATDE EIAAHEARLD LVQKKGGSCL WRA
Length

243

Mol. Wt

27.098 kDa

pI

5.9 (calculated)

Extinction coefficient

14,440 - 14,815 (calc based on 6 Y, 1 W, and 3 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

8..175

PF00929 Exonuclease

PMID:19920124[8]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=dnaQ taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128202

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:946441

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0000722

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P03007

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10243

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10243

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:946441

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000237

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0239

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 5.12 5.13 5.14 5.15 5.16 5.17 5.18 5.19 5.20 5.21 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  6. ↑ 6.0 6.1 6.2 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  7. ↑ 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  8. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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