der:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

Der

Synonyms

predicted GTP-binding protein[1], B2511[2][1], Der[2][1], YfgK[2][1], EngA[2][1] , ECK2507, engA, JW5403, yfgK, b2511

Product description

50S ribosomal subunit stability factor[2][3]

Multicopy suppressor of ftsJ; depleted cells form filaments with defective chromosome segregation; GTPase[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc (v14.0)

complete

GO:0005525

GTP binding

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00195

F

Seeded from EcoCyc (v14.0)

complete

GO:0005525

GTP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002917

F

Seeded from EcoCyc (v14.0)

complete

GO:0005525

GTP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005225

F

Seeded from EcoCyc (v14.0)

complete

GO:0005525

GTP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006073

F

Seeded from EcoCyc (v14.0)

complete

GO:0005525

GTP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016484

F

Seeded from EcoCyc (v14.0)

complete

GO:0005525

GTP binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0342

F

Seeded from EcoCyc (v14.0)

complete

GO:0005622

intracellular

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002917

C

Seeded from EcoCyc (v14.0)

complete

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

ynbC

PMID:15690043[5]

Experiment(s):EBI-878632

Protein

rplB

PMID:15690043[5]

Experiment(s):EBI-878632

Protein

rplD

PMID:15690043[5]

Experiment(s):EBI-878632

Protein

rplN

PMID:15690043[5]

Experiment(s):EBI-878632

Protein

rpsB

PMID:15690043[5]

Experiment(s):EBI-878632

Protein

rpsC

PMID:15690043[5]

Experiment(s):EBI-878632

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc

MRCLMIYKNE ALNMVPVVAL VGRPNVGKST LFNRLTRTRD ALVADFPGLT RDRKYGRAEI
EGREFICIDT GGIDGTEDGV ETRMAEQSLL AIEEADVVLF MVDARAGLMP ADEAIAKHLR
SREKPTFLVA NKTDGLDPDQ AVVDFYSLGL GEIYPIAASH GRGVLSLLEH VLLPWMEDLA
PQEEVDEDAE YWAQFEAEEN GEEEEEDDFD PQSLPIKLAI VGRPNVGKST LTNRILGEER
VVVYDMPGTT RDSIYIPMER DGREYVLIDT AGVRKRGKIT DAVEKFSVIK TLQAIEDANV
VMLVIDAREG ISDQDLSLLG FILNSGRSLV IVVNKWDGLS QEVKEQVKET LDFRLGFIDF
ARVHFISALH GSGVGNLFES VREAYDSSTR RVGTSMLTRI MTMAVEDHQP PLVRGRRVKL
KYAHAGGYNP PIVVIHGNQV KDLPDSYKRY LMNYFRKSLD VMGSPIRIQF KEGENPYANK
RNTLTPTQMR KRKRLMKHIK KNK
Length

503

Mol. Wt

56.617 kDa

pI

5.8 (calculated)

Extinction coefficient

38,850 - 39,100 (calc based on 15 Y, 3 W, and 2 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

14..119

PF01926 GTPase of unknown function

PMID:19920124[6]

Domain

214..322

PF01926 GTPase of unknown function

PMID:19920124[6]

<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=der taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:90111450

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:946983

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0008270

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A6P5

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G7319

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG14207

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:946983

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120003891

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB3959

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. 5.0 5.1 5.2 5.3 5.4 5.5 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  6. 6.0 6.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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