csdA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

CsdA

Synonyms

cysteine sulfinate desulfinase[1], B2810[2][1], YgdJ[2][1], CsdA[2][1] , ECK2806, JW2781, ygdJ, b2810

Product description

G7454[2][3];

Component of cysteine sulfinate desulfinase[3]

Cysteine desulfurase, stimulated by CsdE[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000096

sulfur amino acid metabolic process

PMID:9278392[5]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc (v14.0)

complete

GO:0005515

protein binding

PMID:15690043[6]

IPI: Inferred from Physical Interaction

UniProtKB:P15877

F

Seeded from EcoCyc (v14.0)

complete

GO:0005515

protein binding

PMID:15901727[7]

IPI: Inferred from Physical Interaction

UniProtKB:P0AGF2

F

Seeded from EcoCyc (v14.0)

complete

GO:0016783

sulfurtransferase activity

PMID:11290749[8]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0016829

lyase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0456

F

Seeded from EcoCyc (v14.0)

complete

GO:0030170

pyridoxal phosphate binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015421

F

Seeded from EcoCyc (v14.0)

complete

GO:0030170

pyridoxal phosphate binding

PMID:9278392[5]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of cysteine sulfinate desulfinase

could be indirect

Protein

nadE

PMID:16606699[9]

Experiment(s):EBI-1144031

Protein

groL

PMID:16606699[9]

Experiment(s):EBI-1144031

Protein

dapE

PMID:16606699[9]

Experiment(s):EBI-1144031

Protein

gcd

PMID:15690043[6]

Experiment(s):EBI-894875

Protein

gcd

PMID:19402753[10]

LCMS(ID Probability):99.6

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MNVFNPAQFR AQFPALQDAG VYLDSAATAL KPEAVVEATQ QFYSLSAGNV HRSQFAEAQR
LTARYEAARE KVAQLLNAPD DKTIVWTRGT TESINMVAQC YARPRLQPGD EIIVSVAEHH
ANLVPWLMVA QQTGAKVVKL PLNAQRLPDV DLLPELITPR SRILALGQMS NVTGGCPDLA
RAITFAHSAG MVVMVDGAQG AVHFPADVQQ LDIDFYAFSG HKLYGPTGIG VLYGKSELLE
AMSPWLGGGK MVHEVSFDGF TTQSAPWKLE AGTPNVAGVI GLSAALEWLA DYDINQAESW
SRSLATLAED ALAKRPGFRS FRCQDSSLLA FDFAGVHHSD MVTLLAEYGI ALRAGQHCAQ
PLLAELGVTG TLRASFAPYN TKSDVDALVN AVDRALELLV D
Length

401

Mol. Wt

43.233 kDa

pI

5.3 (calculated)

Extinction coefficient

47,900 - 48,400 (calc based on 10 Y, 6 W, and 4 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

21..388

PF00266 Aminotransferase class-V

PMID:19920124[11]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=csdA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16130717

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947275

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0009218

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:Q46925

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G7454

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG13082

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947275

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120004017

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB2891

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 Mihara, H et al. (1997) Cysteine sulfinate desulfinase, a NIFS-like protein of Escherichia coli with selenocysteine lyase and cysteine desulfurase activities. Gene cloning, purification, and characterization of a novel pyridoxal enzyme. J. Biol. Chem. 272 22417-24 PubMed
  6. ↑ 6.0 6.1 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  7. ↑ Loiseau, L et al. (2005) Analysis of the heteromeric CsdA-CsdE cysteine desulfurase, assisting Fe-S cluster biogenesis in Escherichia coli. J. Biol. Chem. 280 26760-9 PubMed
  8. ↑ Leimkühler, S & Rajagopalan, KV (2001) A sulfurtransferase is required in the transfer of cysteine sulfur in the in vitro synthesis of molybdopterin from precursor Z in Escherichia coli. J. Biol. Chem. 276 22024-31 PubMed
  9. ↑ 9.0 9.1 9.2 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  10. ↑ Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  11. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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