cpxR:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

CpxR

Synonyms

B3912[1][2], YiiA[1][2], ECK3905, JW3883, yiiA, b3912

Product description

DNA-binding response regulator in two-component regulatory system with CpxA[2] Response regulator, periplasmic stress response; CpxA is cognate sensor protein[3]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000156

two-component response regulator activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001789

F

Seeded from EcoCyc (v14.0)

complete

GO:0000156

two-component response regulator activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001867

F

Seeded from EcoCyc (v14.0)

complete

GO:0000160

two-component signal transduction system (phosphorelay)

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001789

P

Seeded from EcoCyc (v14.0)

complete

GO:0000160

two-component signal transduction system (phosphorelay)

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001867

P

Seeded from EcoCyc (v14.0)

complete

GO:0000160

two-component signal transduction system (phosphorelay)

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0902

P

Seeded from EcoCyc (v14.0)

complete

GO:0003700

transcription factor activity

PMID:15686558[4]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0003700

transcription factor activity

PMID:16077119[5]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0003700

transcription factor activity

PMID:7883164[6]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0003700

transcription factor activity

PMID:8294007[7]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P0AA16
UniProtKB:P0A9Q1
UniProtKB:P07545
UniProtKB:P13792
UniProtKB:Q06239
UniProtKB:P0AFJ5
UniProtKB:P08368
UniProtKB:P22104
UniProtKB:P21866

F

Seeded from EcoCyc (v14.0)

complete

GO:0003700

transcription factor activity

PMID:9159398[8]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0016563

transcription activator activity

PMID:15686558[4]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0016563

transcription activator activity

PMID:16077119[5]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0016563

transcription activator activity

PMID:7883164[6]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0016563

transcription activator activity

PMID:8294007[7]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P0AA16
UniProtKB:P0A9Q1
UniProtKB:P07545
UniProtKB:P13792
UniProtKB:Q06239
UniProtKB:P0AFJ5
UniProtKB:P08368
UniProtKB:P22104
UniProtKB:P21866

F

Seeded from EcoCyc (v14.0)

complete

GO:0016563

transcription activator activity

PMID:9159398[8]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0016566

specific transcriptional repressor activity

PMID:15686558[4]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0016566

specific transcriptional repressor activity

PMID:16077119[5]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0016566

specific transcriptional repressor activity

PMID:7883164[6]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0016566

specific transcriptional repressor activity

PMID:8294007[7]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P0AA16
UniProtKB:P0A9Q1
UniProtKB:P07545
UniProtKB:P13792
UniProtKB:Q06239
UniProtKB:P0AFJ5
UniProtKB:P08368
UniProtKB:P22104
UniProtKB:P21866

F

Seeded from EcoCyc (v14.0)

complete

GO:0016566

specific transcriptional repressor activity

PMID:9159398[8]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0032582

negative regulation of gene-specific transcription

PMID:15686558[4]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc (v14.0)

complete

GO:0032582

negative regulation of gene-specific transcription

PMID:16077119[5]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc (v14.0)

complete

GO:0032582

negative regulation of gene-specific transcription

PMID:7883164[6]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc (v14.0)

complete

GO:0032582

negative regulation of gene-specific transcription

PMID:8294007[7]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P0AA16
UniProtKB:P0A9Q1
UniProtKB:P07545
UniProtKB:P13792
UniProtKB:Q06239
UniProtKB:P0AFJ5
UniProtKB:P08368
UniProtKB:P22104
UniProtKB:P21866

P

Seeded from EcoCyc (v14.0)

complete

GO:0032582

negative regulation of gene-specific transcription

PMID:9159398[8]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc (v14.0)

complete

GO:0043193

positive regulation of gene-specific transcription

PMID:15686558[4]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc (v14.0)

complete

GO:0043193

positive regulation of gene-specific transcription

PMID:16077119[5]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc (v14.0)

complete

GO:0043193

positive regulation of gene-specific transcription

PMID:7883164[6]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc (v14.0)

complete

GO:0043193

positive regulation of gene-specific transcription

PMID:8294007[7]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P0AA16
UniProtKB:P0A9Q1
UniProtKB:P07545
UniProtKB:P13792
UniProtKB:Q06239
UniProtKB:P0AFJ5
UniProtKB:P08368
UniProtKB:P22104
UniProtKB:P21866

P

Seeded from EcoCyc (v14.0)

complete

GO:0043193

positive regulation of gene-specific transcription

PMID:9159398[8]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc (v14.0)

complete

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Interactions

See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

cysI

PMID:16606699[9]

Experiment(s):EBI-1146994

Protein

recD

PMID:16606699[9]

Experiment(s):EBI-1146994

Protein

murE

PMID:16606699[9]

Experiment(s):EBI-1146994

Protein

aaeA

PMID:16606699[9]

Experiment(s):EBI-1146994
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

cytoplasm

From EcoCyc[10]


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MNKILLVDDD RELTSLLKEL LEMEGFNVIV AHDGEQALDL LDDSIDLLLL DVMMPKKNGI
DTLKALRQTH QTPVIMLTAR GSELDRVLGL ELGADDYLPK PFNDRELVAR IRAILRRSHW
SEQQQNNDNG SPTLEVDALV LNPGRQEASF DGQTLELTGT EFTLLYLLAQ HLGQVVSREH
LSQEVLGKRL TPFDRAIDMH ISNLRRKLPD RKDGHPWFKT LRGRGYLMVS AS
Length

232

Mol. Wt

26.312 kDa

pI

5.5 (calculated)

Extinction coefficient

15,470 (calc based on 3 Y, 2 W, and 0 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

152..228

PF00486 Transcriptional regulatory protein, C terminal

PMID:19920124[11]

Domain

4..112

PF00072 Response regulator receiver domain

PMID:19920124[11]

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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=cpxR taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16131752

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948404

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0012774

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0AE88

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10020

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10020

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948404

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000017

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0019

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  2. ↑ 2.0 2.1 2.2 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  3. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Hirakawa, H et al. (2005) Indole induces the expression of multidrug exporter genes in Escherichia coli. Mol. Microbiol. 55 1113-26 PubMed
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Batchelor, E et al. (2005) The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC. J. Bacteriol. 187 5723-31 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 6.4 Danese, PN et al. (1995) The Cpx two-component signal transduction pathway of Escherichia coli regulates transcription of the gene specifying the stress-inducible periplasmic protease, DegP. Genes Dev. 9 387-98 PubMed
  7. ↑ 7.0 7.1 7.2 7.3 7.4 Dong, J et al. (1993) The deduced amino-acid sequence of the cloned cpxR gene suggests the protein is the cognate regulator for the membrane sensor, CpxA, in a two-component signal transduction system of Escherichia coli. Gene 136 227-30 PubMed
  8. ↑ 8.0 8.1 8.2 8.3 8.4 Pogliano, J et al. (1997) Regulation of Escherichia coli cell envelope proteins involved in protein folding and degradation by the Cpx two-component system. Genes Dev. 11 1169-82 PubMed
  9. ↑ 9.0 9.1 9.2 9.3 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  10. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  11. ↑ 11.0 11.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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