cbpA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

CbpA

Synonyms

curved DNA-binding protein, DnaJ homologue that functions as a co-chaperone of DnaK[1], B1000[2][1], CbpA[2][1] , ECK0991, JW0985, b1000

Product description

CbpA[2][3];

Component of chaperone with DnaK; curved DNA-binding protein[3]

DnaK co-chaperone; also binds curved DNA[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003677

DNA binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

Seeded from EcoCyc (v14.0)

complete

GO:0003681

bent DNA binding

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01154

F

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_01154

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0006457

protein folding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002939

P

Seeded from EcoCyc (v14.0)

complete

GO:0006457

protein folding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003095

P

Seeded from EcoCyc (v14.0)

complete

GO:0006457

protein folding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008971

P

Seeded from EcoCyc (v14.0)

complete

GO:0003681

bent DNA binding

PMID:10551881[5]

IDA: Inferred from Direct Assay

F

complete

GO:0009295

nucleoid

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0187

C

Seeded from EcoCyc (v14.0)

complete

GO:0031072

heat shock protein binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001623

F

Seeded from EcoCyc (v14.0)

complete

GO:0031072

heat shock protein binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003095

F

Seeded from EcoCyc (v14.0)

complete

GO:0031072

heat shock protein binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018253

F

Seeded from EcoCyc (v14.0)

complete

GO:0051082

unfolded protein binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002939

F

Seeded from EcoCyc (v14.0)

complete

GO:0051082

unfolded protein binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003095

F

Seeded from EcoCyc (v14.0)

complete

GO:0051082

unfolded protein binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008971

F

Seeded from EcoCyc (v14.0)

complete

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of chaperone with DnaK; curved DNA-binding protein

could be indirect

Protein

prsA

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

rplI

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

rplS

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

rplV

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

rplX

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

rpoC

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

rpsA

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

rpsB

PMID:15690043[6]

Experiment(s):EBI-885677, EBI-892312

Protein

rpsC

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

rpsD

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

rpsE

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

rpsG

PMID:15690043[6]

Experiment(s):EBI-885677, EBI-892312

Protein

rpsM

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

srmB

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

tufA

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

ygiF

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

aidB

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

clpA

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

clpB

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

deaD

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

dnaK

PMID:15690043[6]

Experiment(s):EBI-885677, EBI-892312

Protein

fabZ

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

hscA

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

infC

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

metK

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

mukB

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

rho

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

rplA

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

rplB

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

rplC

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

rplD

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

rplE

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

rplF

PMID:15690043[6]

Experiment(s):EBI-885677

Protein

rbsK

PMID:15690043[6]

Experiment(s):EBI-892312

Protein

rplL

PMID:15690043[6]

Experiment(s):EBI-892312

Protein

rpmC

PMID:15690043[6]

Experiment(s):EBI-892312

Protein

rpmG

PMID:15690043[6]

Experiment(s):EBI-892312

Protein

rpsP

PMID:15690043[6]

Experiment(s):EBI-892312

Protein

ugpB

PMID:15690043[6]

Experiment(s):EBI-892312

Protein

yfbT

PMID:15690043[6]

Experiment(s):EBI-892312

Protein

tusC

PMID:15690043[6]

Experiment(s):EBI-892312

Protein

yjfK

PMID:15690043[6]

Experiment(s):EBI-892312

Protein

dnaK

PMID:16606699[7]

Experiment(s):EBI-1138573

Protein

nadE

PMID:16606699[7]

Experiment(s):EBI-1138573

Protein

rplB

PMID:16606699[7]

Experiment(s):EBI-1138573

Protein

groL

PMID:16606699[7]

Experiment(s):EBI-1138573

Protein

yjeJ

PMID:16606699[7]

Experiment(s):EBI-1138573

Protein

lon

PMID:16606699[7]

Experiment(s):EBI-1138573

Protein

rplD

PMID:16606699[7]

Experiment(s):EBI-1138573

Protein

clpB

PMID:19402753[8]

MALDI(Z-score):27.504284

Protein

rho

PMID:19402753[8]

MALDI(Z-score):21.053215

Protein

rpsA

PMID:19402753[8]

MALDI(Z-score):27.245363

Protein

rplE

PMID:19402753[8]

MALDI(Z-score):19.295909

Protein

rplA

PMID:19402753[8]

MALDI(Z-score):37.280442

Protein

rpsP

PMID:19402753[8]

LCMS(ID Probability):99.0 MALDI(Z-score):7.246406

Protein

hscA

PMID:19402753[8]

MALDI(Z-score):25.137081

Protein

rplI

PMID:19402753[8]

MALDI(Z-score):35.692345

Protein

rplB

PMID:19402753[8]

MALDI(Z-score):37.179958

Protein

rpsC

PMID:19402753[8]

MALDI(Z-score):35.519024

Protein

rpsD

PMID:19402753[8]

MALDI(Z-score):35.014930

Protein

yfbT

PMID:19402753[8]

LCMS(ID Probability):99.0

Protein

prs

PMID:19402753[8]

MALDI(Z-score):22.031238

Protein

yheM

PMID:19402753[8]

LCMS(ID Probability):99.0

Protein

deaD

PMID:19402753[8]

MALDI(Z-score):44.936161

Protein

rplD

PMID:19402753[8]

MALDI(Z-score):22.772047

Protein

rluB

PMID:19402753[8]

MALDI(Z-score):28.818571

Protein

yjfK

PMID:19402753[8]

LCMS(ID Probability):99.0

Protein

rbsK

PMID:19402753[8]

LCMS(ID Probability):99.0

</protect>

Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc

MELKDYYAIM GVKPTDDLKT IKTAYRRLAR KYHPDVSKEP DAEARFKEVA EAWEVLSDEQ
RRAEYDQMWQ HRNDPQFNRQ FHHGDGQSFN AEDFDDIFSS IFGQHARQSR QRPATRGHDI
EIEVAVFLEE TLTEHKRTIS YNLPVYNAFG MIEQEIPKTL NVKIPAGVGN GQRIRLKGQG
TPGENGGPNG DLWLVIHIAP HPLFDIVGQD LEIVVPVSPW EAALGAKVTV PTLKESILLT
IPPGSQAGQR LRVKGKGLVS KKQTGDLYAV LKIVMPPKPD ENTAALWQQL ADAQSSFDPR
KDWGKA
Length

306

Mol. Wt

34.455 kDa

pI

6.8 (calculated)

Extinction coefficient

44,920 (calc based on 8 Y, 6 W, and 0 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

5..66

PF00226 DnaJ domain

PMID:19920124[9]

Domain

190..286

PF01556 DnaJ C terminal region

PMID:19920124[9]

<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=cbpA taxon=562,83333 </beststructure>

Models

View models at:

</protect>

Structure figures

<protect>

</protect>

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference

<protect></protect>

Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128966

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947572

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0003379

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P36659

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG12193

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG12193

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947572

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120002082

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB2110

Escherichia coli str. K-12 substr. MG1655

<protect></protect>

Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. Azam, TA & Ishihama, A (1999) Twelve species of the nucleoid-associated protein from Escherichia coli. Sequence recognition specificity and DNA binding affinity. J. Biol. Chem. 274 33105-13 PubMed
  6. 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 6.12 6.13 6.14 6.15 6.16 6.17 6.18 6.19 6.20 6.21 6.22 6.23 6.24 6.25 6.26 6.27 6.28 6.29 6.30 6.31 6.32 6.33 6.34 6.35 6.36 6.37 6.38 6.39 6.40 6.41 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  7. 7.0 7.1 7.2 7.3 7.4 7.5 7.6 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  8. 8.00 8.01 8.02 8.03 8.04 8.05 8.06 8.07 8.08 8.09 8.10 8.11 8.12 8.13 8.14 8.15 8.16 8.17 8.18 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  9. 9.0 9.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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