birA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

BirA

Synonyms

bifunctional biotin-[acetylCoA carboxylase] holoenzyme synthetase and DNA-binding transcriptional repressor, bio-5'-AMP-binding[1], B3973[2][1], BirA[2][1], BioR[2][1], DhbB[2][1], biotin-[acetylCoA carboxylase] holoenzyme synthetase and biotin operon repressor[2][1], biotin ligase[2][1], BirA transcriptional repressor[2][1] , bioR, dhbB, ECK3965, JW3941, b3973

Product description

Bifunctional biotin protein ligase, biotin operon repressor; biotin-[acetyl-CoA carboxylase] holoenzyme synthase; monomeric[3]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

Seeded from EcoCyc (v14.0)

complete

GO:0003824

catalytic activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004143

F

Seeded from EcoCyc (v14.0)

complete

GO:0004077

biotin-(acetyl-CoA-carboxylase) ligase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004408

F

Seeded from EcoCyc (v14.0)

complete

GO:0004077

biotin-(acetyl-CoA-carboxylase) ligase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:6.3.4.15

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

Seeded from EcoCyc (v14.0)

complete

GO:0006350

transcription

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0804

P

Seeded from EcoCyc (v14.0)

complete

GO:0009102

biotin biosynthetic process

PMID:6456358[4]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0006355

regulation of transcription, DNA-dependent

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004409

P

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

PMID:6456358[4]

IC: Inferred by Curator

C

Missing: with/from

GO:0006464

protein modification process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003142

P

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

PMID:6456358[4]

IDA: Inferred from Direct Assay

F

complete

GO:0006464

protein modification process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004143

P

Seeded from EcoCyc (v14.0)

complete

GO:0016564

transcription repressor activity

PMID:6456358[4]

IEP: Inferred from Expression Pattern

F

complete

GO:0006464

protein modification process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004408

P

Seeded from EcoCyc (v14.0)

complete

GO:0004077

biotin-(acetyl-CoA-carboxylase) ligase activity

PMID:7024555[5]

IDA: Inferred from Direct Assay

F

complete

GO:0016564

transcription repressor activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004409

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

nanE

PMID:15690043[6]

Experiment(s):EBI-879022

Protein

glpB

PMID:15690043[6]

Experiment(s):EBI-882266

Protein

nfrB

PMID:15690043[6]

Experiment(s):EBI-882266

Protein

rplU

PMID:15690043[6]

Experiment(s):EBI-882266

Protein

rplV

PMID:15690043[6]

Experiment(s):EBI-882266

Protein

rpsC

PMID:15690043[6]

Experiment(s):EBI-882266

Protein

rpsN

PMID:15690043[6]

Experiment(s):EBI-882266

Protein

rplU

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rpsN

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

nanE

PMID:19402753[7]

MALDI(Z-score):38.087873

Protein

glpB

PMID:19402753[7]

LCMS(ID Probability):99.6

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

cytoplasm

From EcoCyc[8]


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MKDNTVPLKL IALLANGEFH SGEQLGETLG MSRAAINKHI QTLRDWGVDV FTVPGKGYSL
PEPIQLLNAK QILGQLDGGS VAVLPVIDST NQYLLDRIGE LKSGDACIAE YQQAGRGRRG
RKWFSPFGAN LYLSMFWRLE QGPAAAIGLS LVIGIVMAEV LRKLGADKVR VKWPNDLYLQ
DRKLAGILVE LTGKTGDAAQ IVIGAGINMA MRRVEESVVN QGWITLQEAG INLDRNTLAA
MLIRELRAAL ELFEQEGLAP YLSRWEKLDN FINRPVKLII GDKEIFGISR GIDKQGALLL
EQDGIIKPWM GGEISLRSAE K
Length

321

Mol. Wt

35.313 kDa

pI

8.1 (calculated)

Extinction coefficient

47,440 - 47,565 (calc based on 6 Y, 7 W, and 1 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

271..317

PF02237 Biotin protein ligase C terminal domain

PMID:19920124[9]

Domain

83..208

PF03099 Biotin/lipoate A/B protein ligase family

PMID:19920124[9]

Domain

8..59

PF08279 HTH domain

PMID:19920124[9]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=birA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16131807

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948469

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0013001

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P06709

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10123

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10123

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948469

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000119

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0121

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  4. ↑ 4.0 4.1 4.2 4.3 Barker, DF & Campbell, AM (1981) Genetic and biochemical characterization of the birA gene and its product: evidence for a direct role of biotin holoenzyme synthetase in repression of the biotin operon in Escherichia coli. J. Mol. Biol. 146 469-92 PubMed
  5. ↑ Barker, DF & Campbell, AM (1981) The birA gene of Escherichia coli encodes a biotin holoenzyme synthetase. J. Mol. Biol. 146 451-67 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  7. ↑ 7.0 7.1 7.2 7.3 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  8. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  9. ↑ 9.0 9.1 9.2 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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