apaH:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

ApaH

Synonyms

diadenosine tetraphosphatase[1], B0049[2][1], CfcB[2][1], ApaH[2][1] , cfcB, ECK0050, JW0048, b0049

Product description

diadenosine tetraphosphatase[2][3]

Dinucleoside tetraphosphatase, symmetrical; diadenosine tetraphosphatase; bis(5'-nucleosyl)-tetraphosphatase, symmetrical[4]

EC number (for enzymes)
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Notes

ApaH catalyzes the reaction 5',5'''-diadenosine tetraphosphate + H2O <=> 2 ADP + 2 H+

See the reaction at [EcoCyc]

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0008803

bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00199

F

Seeded from EcoCyc (v14.0)

complete

GO:0008803

bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004617

F

Seeded from EcoCyc (v14.0)

complete

GO:0008803

bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.6.1.41

F

Seeded from EcoCyc (v14.0)

complete

GO:0016787

hydrolase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004843

F

Seeded from EcoCyc (v14.0)

complete

GO:0016787

hydrolase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0378

F

Seeded from EcoCyc (v14.0)

complete

GO:0008796

bis(5'-nucleosyl)-tetraphosphatase activity

PMID:2995325[5]

IMP: Inferred from Mutant Phenotype

F

Fig. 4

complete

GO:0015949

nucleobase, nucleoside and nucleotide interconversion

PMID:2995325[5]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0008803

bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity

PMID:6317672[6]

IDA: Inferred from Direct Assay

F

Table I. Assay described in Materials & Methods.

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

htpG

PMID:16606699[7]

Experiment(s):EBI-1135450

Protein

intD

PMID:16606699[7]

Experiment(s):EBI-1135450

Protein

rplS

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

rpsN

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

rplJ

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

rpsH

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

gapA

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

rplY

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

rpsP

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

eno

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

rpmC

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

yfiD

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

rpsT

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

groS

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

rplA

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

yccJ

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

adk

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

minD

PMID:19402753[8]

LCMS(ID Probability):99.4

Protein

hupB

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

hupA

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

hns

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

tig

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

slyD

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

rne

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

ygiW

PMID:19402753[8]

LCMS(ID Probability):99.4

Protein

efp

PMID:19402753[8]

LCMS(ID Probability):99.6

Protein

hisB

PMID:19402753[8]

LCMS(ID Probability):99.4

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MATYLIGDVH GCYDELIALL HKVEFTPGKD TLWLTGDLVA RGPGSLDVLR YVKSLGDSVR
LVLGNHDLHL LAVFAGISRN KPKDRLTPLL EAPDADELLN WLRRQPLLQI DEEKKLVMAH
AGITPQWDLQ TAKECARDVE AVLSSDSYPF FLDAMYGDMP NNWSPELRGL GRLRFITNAF
TRMRFCFPNG QLDMYSKESP EEAPAPLKPW FAIPGPVAEE YSIAFGHWAS LEGKGTPEGI
YALDTGCCWG GTLTCLRWED KQYFVQPSNR HKDLGEAAAS
Length

280

Mol. Wt

31.297 kDa

pI

5.1 (calculated)

Extinction coefficient

57,410 - 58,160 (calc based on 9 Y, 8 W, and 6 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

1..236

PF00149 Calcineurin-like phosphoesterase

PMID:19920124[9]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=apaH taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128043

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0000167

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P05637

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10048

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10048

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:944770

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000044

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:944770

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0046

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 Mechulam, Y et al. (1985) Molecular cloning of the Escherichia coli gene for diadenosine 5',5-P1,P4-tetraphosphate pyrophosphohydrolase. J. Bacteriol. 164 63-9 PubMed
  6. ↑ Guranowski, A et al. (1983) Catabolism of diadenosine 5',5"'-P1,P4-tetraphosphate in procaryotes. Purification and properties of diadenosine 5',5"'-P1,P4-tetraphosphate (symmetrical) pyrophosphohydrolase from Escherichia coli K12. J. Biol. Chem. 258 14784-9 PubMed
  7. ↑ 7.0 7.1 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  8. ↑ 8.00 8.01 8.02 8.03 8.04 8.05 8.06 8.07 8.08 8.09 8.10 8.11 8.12 8.13 8.14 8.15 8.16 8.17 8.18 8.19 8.20 8.21 8.22 8.23 8.24 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  9. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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