aidB:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

AidB

Synonyms

isovaleryl CoA dehydrogenase[1], B4187[2][1], AidB[2][1] , ECK4183, JW5867, b4187

Product description

EG11811- Flavin-containing, DNA binding protein; low level isovaleryl CoA dehydrogenase activity; Ada-regulated adaptive response to DNA methylation damage[3]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006089

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006090

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006091

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009075

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009100

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013764

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

P

Seeded from EcoCyc (v14.0)

complete

GO:0005515

protein binding

PMID:18829440[4]

IPI: Inferred from Physical Interaction

EcoliWiki:aidB


F

AidB is a homotetramer (Figure 2).

complete

GO:0003677

DNA binding

PMID:18829440[4]

IPI: Inferred from Physical Interaction

F

Missing: with/from

GO:0050660

FAD binding

PMID:18829440[4]

IPI: Inferred from Physical Interaction

F

Missing: with/from

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

aceF

PMID:15690043[5]

Experiment(s):EBI-881555, EBI-888995

Protein

dnaK

PMID:15690043[5]

Experiment(s):EBI-881555, EBI-888995

Protein

groL

PMID:15690043[5]

Experiment(s):EBI-881555, EBI-888995

Protein

hldD

PMID:15690043[5]

Experiment(s):EBI-881555

Protein

rplC

PMID:15690043[5]

Experiment(s):EBI-881555, EBI-888995

Protein

rpsD

PMID:15690043[5]

Experiment(s):EBI-881555

Protein

rplA

PMID:15690043[5]

Experiment(s):EBI-888995

Protein

rplM

PMID:15690043[5]

Experiment(s):EBI-888995

Protein

rplS

PMID:15690043[5]

Experiment(s):EBI-888995

Protein

rplU

PMID:15690043[5]

Experiment(s):EBI-888995

Protein

rplV

PMID:15690043[5]

Experiment(s):EBI-888995

Protein

rpmB

PMID:15690043[5]

Experiment(s):EBI-888995

Protein

rpsB

PMID:15690043[5]

Experiment(s):EBI-888995

Protein

rpsE

PMID:15690043[5]

Experiment(s):EBI-888995

Protein

rpsF

PMID:15690043[5]

Experiment(s):EBI-888995

Protein

rpsG

PMID:15690043[5]

Experiment(s):EBI-888995

Protein

rpsL

PMID:15690043[5]

Experiment(s):EBI-888995

Protein

rpsN

PMID:15690043[5]

Experiment(s):EBI-888995

Protein

rpsS

PMID:15690043[5]

Experiment(s):EBI-888995

Protein

rpsT

PMID:15690043[5]

Experiment(s):EBI-888995

Protein

yhbY

PMID:15690043[5]

Experiment(s):EBI-888995

Protein

yjgD

PMID:15690043[5]

Experiment(s):EBI-888995

Protein

groL

PMID:19402753[6]

LCMS(ID Probability):99.6 MALDI(Z-score):17.053160

Protein

rpsL

PMID:19402753[6]

LCMS(ID Probability):99.6

Protein

rpsS

PMID:19402753[6]

LCMS(ID Probability):99.6

Protein

rraB

PMID:19402753[6]

LCMS(ID Probability):99.6

Protein

groS

PMID:19402753[6]

LCMS(ID Probability):99.6 MALDI(Z-score):27.610802

Protein

rfaD

PMID:19402753[6]

MALDI(Z-score):38.923930

Protein

rplU

PMID:19402753[6]

LCMS(ID Probability):99.4

Protein

rpsT

PMID:19402753[6]

LCMS(ID Probability):99.6

Protein

rpsN

PMID:19402753[6]

LCMS(ID Probability):99.6

Protein

rplA

PMID:19402753[6]

LCMS(ID Probability):99.6 MALDI(Z-score):5.981968

Protein

rpsF

PMID:19402753[6]

LCMS(ID Probability):99.6

Protein

rpmB

PMID:19402753[6]

LCMS(ID Probability):99.6

Protein

rplS

PMID:19402753[6]

LCMS(ID Probability):99.6

Protein

rpsD

PMID:19402753[6]

MALDI(Z-score):18.402235

Protein

rplM

PMID:19402753[6]

LCMS(ID Probability):99.6

Protein

yhbY

PMID:19402753[6]

LCMS(ID Probability):99.6

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MEGDTVHWQT HTVFNQPIPL NNSNLYLSDG ALCEAVTREG AGWDSDFLAS IGQQLGTAES
LELGRLANVN PPELLRYDAQ GRRLDDVRFH PAWHLLMQAL CTNRVHNLAW EEDARSGAFV
ARAARFMLHA QVEAGSLCPI TMTFAATPLL LQMLPAPFQD WTTPLLSDRY DSHLLPGGQK
RGLLIGMGMT EKQGGSDVMS NTTRAERLED GSYRLVGHKW FFSVPQSDAH LVLAQTAGGL
SCFFVPRFLP DGQRNAIRLE RLKDKLGNRS NASCEVEFQD AIGWLLGLEG EGIRLILKMG
GMTRFDCALG SHAMMRRAFS LAIYHAHQRH VFGNPLIQQP LMRHVLSRMA LQLEGQTALL
FRLARAWDRR ADAKEALWAR LFTPAAKFVI CKRGMPFVAE AMEVLGGIGY CEESELPRLY
REMPVNSIWE GSGNIMCLDV LRVLNKQAGV YDLLSEAFVE VKGQDRYFDR AVRRLQQQLR
KPAEELGREI THQLFLLGCG AQMLKYASPP MAQAWCQVML DTRGGVRLSE QIQNDLLLRA
TGGVCV
Length

546

Mol. Wt

61.092 kDa

pI

7.5 (calculated)

Extinction coefficient

75,400 - 76,900 (calc based on 10 Y, 11 W, and 12 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

285..440

PF00441 Acyl-CoA dehydrogenase, C-terminal domain

PMID:19920124[7]

Domain

181..233

PF02770 Acyl-CoA dehydrogenase, middle domain

PMID:19920124[7]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=aidB taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:162135915

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948710

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0013701

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P33224

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11811

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11811

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948710

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001745

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1759

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  4. ↑ 4.0 4.1 4.2 Bowles, T et al. (2008) Structure and DNA binding of alkylation response protein AidB. Proc. Natl. Acad. Sci. U.S.A. 105 15299-304 PubMed
  5. ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 5.12 5.13 5.14 5.15 5.16 5.17 5.18 5.19 5.20 5.21 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  6. ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 6.12 6.13 6.14 6.15 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  7. ↑ 7.0 7.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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