aaeR:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

AaeR

Synonyms

predicted DNA-binding transcriptional regulator, efflux system[1], B3243[2][1], YhcS[2][1], AaeR[2][1], QseA[2][1] , ECK3232, JW3212, qseA, yhcS, b3243

Product description

quorum sensing transcriptional regulator of LYSR-type[2][3]

Transcriptional regulator for aaeXAB operon; activates ler in O157:H7[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003677

DNA binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

Seeded from EcoCyc (v14.0)

complete

GO:0003700

transcription factor activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000847

F

Seeded from EcoCyc (v14.0)

complete

GO:0006350

transcription

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0804

P

Seeded from EcoCyc (v14.0)

complete

GO:0006350

transcription

PMID:15556475[5]

ISS: Inferred from Sequence or Structural Similarity

Swiss-Prot:P03030

P

Seeded from EcoCyc (v14.0)

complete

GO:0006355

regulation of transcription, DNA-dependent

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000847

P

Seeded from EcoCyc (v14.0)

complete

GO:0016563

transcription activator activity

PMID:15556475[5]

ISS: Inferred from Sequence or Structural Similarity

Swiss-Prot:P03030

F

Seeded from EcoCyc (v14.0)

complete

GO:0006355

regulation of transcription, DNA-dependent

PMID:15489430[6]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0006351

transcription, DNA-dependent

PMID:15489430[6]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0006352

transcription initiation, DNA-dependent

PMID:15489430[6]

IMP: Inferred from Mutant Phenotype

P

replaces obsoleteGO:0016563

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

prs

PMID:16606699[7]

Experiment(s):EBI-1145275

Protein

ytfQ

PMID:16606699[7]

Experiment(s):EBI-1145275

Protein

lsrB

PMID:16606699[7]

Experiment(s):EBI-1145275
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MERLKRMSVF AKVVEFGSFT AAARQLQMSV SSISQTVSKL EDELQVKLLN RSTRSIGLTE
AGRIYYQGCR RMLHEVQDVH EQLYAFNNTP IGTLRIGCSS TMAQNVLAGL TAKMLKEYPG
LSVNLVTGIP APDLIADGLD VVIRVGALQD SSLFSRRLGA MPMVVCAAKS YLTQYGIPEK
PADLSSHSWL EYSVRPDNEF ELIAPEGIST RLIPQGRFVT NDPMTLVRWL TAGAGIAYVP
LMWVINEINR GELEILLPRY QSDPRPVYAL YTEKDKLPLK VQVVINSLTD YFVEVGKLFQ
EMHGRGKEK
Length

309

Mol. Wt

34.516 kDa

pI

8.4 (calculated)

Extinction coefficient

34,380 - 34,755 (calc based on 12 Y, 3 W, and 3 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

87..293

PF03466 LysR substrate binding domain

PMID:19920124[8]

Domain

4..63

PF00126 Bacterial regulatory helix-turn-helix protein, lysR family

PMID:19920124[8]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=aaeR taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16131133

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947760

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0010639

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P67662

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G7688

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG12825

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947760

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120004235

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB2676

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 Pérez-Rueda, E et al. (2004) Phylogenetic distribution of DNA-binding transcription factors in bacteria and archaea. Comput Biol Chem 28 341-50 PubMed
  6. ↑ 6.0 6.1 6.2 Van Dyk, TK et al. (2004) Characterization of the Escherichia coli AaeAB efflux pump: a metabolic relief valve? J. Bacteriol. 186 7196-204 PubMed
  7. ↑ 7.0 7.1 7.2 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  8. ↑ 8.0 8.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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