Plasmid F ccdB:Gene Product(s)
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| Nomenclature | Function | Interactions | Localization | Sequence | Domains | Structure | Resources | Accessions | Links | References | Suggestions |
Nomenclature
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| Standard name |
ccdB |
|---|---|
| Synonyms |
ccdB, Fpla045 |
| Product description |
ccdB toxin protein; is more stable than CcdA; inhibits DNA gyrase which functions during DNA replication to catalyze negative supercoiling; involved in post-segregation killing |
| EC number (for enzymes) |
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Notes
Function
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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:2000245 |
negative regulation of cytokinesis by binary fission |
IMP: Inferred from Mutant Phenotype |
P |
See Table 3 and Fig. 2. |
complete | |||
| GO:2000372 |
negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity |
IDA: Inferred from Direct Assay |
P |
See Fig 3. |
complete | |||
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Interactions <protect> See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
| Partner Type | Partner | Notes | References | Evidence |
|---|---|---|---|---|
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Notes
Localization
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| Compartment | Description | Evidence | Reference/Source | Notes |
|---|---|---|---|---|
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Notes
Structure and Physical Properties
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Physical Properties
See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
| Name | |
|---|---|
| Sequence |
MQFKVYTYKR ESRYRLFVDV QSDIIDTPGR RMVIPLASAR LLSDKVSREL YPVVHIGDES WRMMTTDMAS VPVSVIGEEV ADLSHRENDI KNAINLMFWG I |
| Length |
101 |
| Mol. Wt |
11.706 kDa |
| pI |
6.5 (calculated) |
| Extinction coefficient |
16,960 (calc based on 4 Y, 2 W, and 0 C residues) |
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Domains/Motifs/Modification Sites
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<motif_map/> |
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Structure
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Structure figures<protect> | ||||||
Notes
Gene Product Resources
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| Resource type | Source | Notes/Reference |
|---|---|---|
| edit table |
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Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
| Database | Accession | Notes |
|---|---|---|
|
EcoCyc: |
Escherichia coli str. K-12 substr. MG1655 | |
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EcoGene: |
Escherichia coli str. K-12 substr. MG1655 | |
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RegulonDB: |
Escherichia coli str. K-12 substr. MG1655 | |
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EchoBASE: |
Escherichia coli str. K-12 substr. MG1655 | |
|
ASAP: |
Escherichia coli str. K-12 substr. MG1655 | |
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Notes
Links
| Name | URL | Comments |
|---|---|---|
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References
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- ↑ Miki, T et al. (1984) Control of cell division by sex factor F in Escherichia coli. II. Identification of genes for inhibitor protein and trigger protein on the 42.84-43.6 F segment. J. Mol. Biol. 174 627-46 PubMed
- ↑ Maki, S et al. (1992) Modulation of DNA supercoiling activity of Escherichia coli DNA gyrase by F plasmid proteins. Antagonistic actions of LetA (CcdA) and LetD (CcdB) proteins. J. Biol. Chem. 267 12244-51 PubMed
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