Plasmid F ccdA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

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Standard name

ccdA

Synonyms

ccdA, Fpla044

Product description

ccdA

controlled cell death protein A; antidote protein; reversibly inactivates CcdB; is less stable than CcdB; upon loss of the F plasmid CcdA is degraded by lon protease allowing CcdB toxin to work

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0043069

negative regulation of programmed cell death

PMID:233425[1]

IDA: Inferred from Direct Assay

P

See Table 8.

complete

GO:0097351

toxin-antitoxin pair type II binding

PMID:17007877[2]

IDA: Inferred from Direct Assay

F

See Fig. 4 ccdAR70K used.

complete

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Interactions <protect> See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence
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Notes

Localization

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Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence 
MKQRITVTVD SDSYQLLKAY DVNISGLVST TMQNEARRLR AERWKAENQE GMAEVARFIE
MNGSFADENR DW
Length

72

Mol. Wt

8.371 kDa

pI

4.9 (calculated)

Extinction coefficient

13,980 (calc based on 2 Y, 2 W, and 0 C residues)

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Domains/Motifs/Modification Sites

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Type Residues Description Notes References
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<motif_map/>

Structure
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Structures

<beststructure> gene=Plasmid_F_ccdA taxon=2465 </beststructure>

Models

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc

EcoCyc:

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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  1. ↑ Jacobitz, K et al. (1979) [Three different tumors in a case of synovial sarcoma of the hand]. Handchirurgie 11 239-41 PubMed
  2. ↑ Madl, T et al. (2006) Structural basis for nucleic acid and toxin recognition of the bacterial antitoxin CcdA. J. Mol. Biol. 364 170-85 PubMed

Categories

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