Phage lambda gam:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

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Standard name

gam

Synonyms

gam, lambdap42

Product description

host-nuclease inhibitor protein Gam

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0032076

negative regulation of deoxyribonuclease activity

PMID:4275917[1]

IDA: Inferred from Direct Assay

P

complete

GO:0032076

negative regulation of deoxyribonuclease activity

PMID:126236[2]

IDA: Inferred from Direct Assay

P

complete

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Interactions <protect> See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence
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Notes

Localization

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Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence 
MDINTETEIK QKHSLTPFPV FLISPAFRGR YFHSYFRSSA MNAYYIQDRL EAQSWARHYQ
QLAREEKEAE LADDMEKGLP QHLFESLCID HLQRHGASKK SITRAFDDDV EFQERMAEHI
RYMVETIAHH QVDIDSEV
Length

138

Mol. Wt

16.346 kDa

pI

5.8 (calculated)

Extinction coefficient

14,440 - 14,565 (calc based on 6 Y, 1 W, and 1 C residues)

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Domains/Motifs/Modification Sites

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Type Residues Description Notes References
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<motif_map/>

Structure
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Structures

<beststructure> gene=Phage_lambda_gam taxon=10710 </beststructure>

Models

View models at:

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</protect>

Structure figures

See Help:Jmol in EcoliWiki

Orthorhombic form of gam, PDB 2UUZ
<jmol> <jmolApplet> <color>white</color> <uploadedFileContents >2UUZ.pdb</uploadedFileContents> <name></name> <script> wireframe off; spacefill off; trace off; rotate ON; cartoon; color chain; </script> </jmolApplet> </jmol>
<jmol> <jmolCheckbox > <scriptWhenChecked > rotate on; </scriptWhenChecked > <scriptWhenUnchecked > rotate off; </scriptWhenUnchecked > <checked>true</checked> <text>rotate</text> </jmolCheckbox > <jmolButton><script>reset; </script><text>reset</text></jmolButton> </jmol>

See Help:Jmol in EcoliWiki

Hexagonal form of gam, PDB:2UV1
<jmol> <jmolApplet> <color>white</color> <uploadedFileContents >2UV1.pdb</uploadedFileContents> <name></name> <script> wireframe off; spacefill off; trace off; rotate ON; cartoon; color chain; </script> </jmolApplet> </jmol>
<jmol> <jmolCheckbox > <scriptWhenChecked > rotate on; </scriptWhenChecked > <scriptWhenUnchecked > rotate off; </scriptWhenUnchecked > <checked>true</checked> <text>rotate</text> </jmolCheckbox > <jmolButton><script>reset; </script><text>reset</text></jmolButton> </jmol>









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Notes

See The crystal structure of lambda-Gam protein suggests a model for RecBCD inhibition[3]for orthorhombic and hexagonal form information.

Gene Product Resources

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Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes
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Notes

Links

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Name URL Comments
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References

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  1. ↑ Sakaki, Y et al. (1973) Purification and properties of the gamma-protein specified by bacteriophage lambda: an inhibitor of the host RecBC recombination enzyme. Proc. Natl. Acad. Sci. U.S.A. 70 2215-9 PubMed
  2. ↑ Karu, AE et al. (1975) The gamma protein specified by bacteriophage gamma. Structure and inhibitory activity for the recBC enzyme of Escherichia coli. J. Biol. Chem. 250 7377-87 PubMed
  3. ↑ Court, R et al. (2007) The crystal structure of lambda-Gam protein suggests a model for RecBCD inhibition. J. Mol. Biol. 371 25-33 PubMed

Categories

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