Phage T7 2:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

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Standard name

2

Synonyms
Product description

inhibits E. coli RNA polymerase

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology <protect> See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
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Interactions <protect> See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence
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Notes

gp2 inhibits transcription by host RNA polymerase[1]. This inhibition is needed to prevent transcription of early promoters late in phage development [2]

Localization

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Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties <protect> See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence 
MSNVNTGSLS VDNKKFWATV ESSEHSFEVP IYAETLDEAL ELAEWQYVPA GFEVTRVRPC VAPK
Length

64

Mol. Wt

7.174 kDa

pI

4.5 (calculated)

Extinction coefficient

13,980 - 14,105 (calc based on 2 Y, 2 W, and 1 C residues)

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Domains/Motifs/Modification Sites

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Type Residues Description Notes References
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Structure
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Structures

<beststructure> gene=Phage_T7_2 taxon=10760 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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<protect> See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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<protect> See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes
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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ Nechaev, S & Severinov, K (1999) Inhibition of Escherichia coli RNA polymerase by bacteriophage T7 gene 2 protein. J. Mol. Biol. 289 815-26 PubMed
  2. ↑ Savalia, D et al. (2010) The role of the T7 Gp2 inhibitor of host RNA polymerase in phage development. J. Mol. Biol. 402 118-26 PubMed

Categories

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