fixC:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

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Standard name

FixC

Synonyms

predicted oxidoreductase with FAD/NAD(P)-binding domain[1], B0043[2][1], YaaS[2][1], FixC[2][1]

Product description

flavoprotein (electron transport), possibly involved in anaerobic carnitine metabolism[2][3]

Related to carnitine metabolism; similarity to Rhizobium fix gene[4]

EC number (for enzymes)


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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0016491

oxidoreductase activity

GO_REF:0000002
GO_REF:0000002
GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR001100
InterPro:IPR003042
InterPro:IPR006076
SP_KW:KW-0560

F

Seeded from EcoCyc 12.5 [5]

complete

GO:0006810

transport

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0813

P

Seeded from EcoCyc [6]

complete

GO:0042413

carnitine catabolic process

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0008152

metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003042

P

Seeded from EcoCyc [6]

complete

GO:0022900

electron transport chain

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0249

P

Seeded from EcoCyc [6]

complete

GO:0055114

oxidation reduction

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

P

Seeded from EcoCyc [6]

complete

GO:0006810

transport

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0813

P

Seeded from EcoCyc

complete

GO:0008152

metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003042

P

Seeded from EcoCyc

complete

GO:0016491

oxidoreductase activity

GO_REF:0000002
GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR003042
InterPro:IPR006076
SP_KW:KW-0560

F

Seeded from EcoCyc

complete

GO:0022900

electron transport chain

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0249

P

Seeded from EcoCyc

complete

GO:0055114

oxidation reduction

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

P

Seeded from EcoCyc

complete

GO:0050660

FAD binding

PMID:17712414[7]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P55931

F

PMID:4052375[8] PMID:17050691[9]

complete

GO:0051536

iron-sulfur cluster binding

PMID:17712414[7]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P55931

F

PMID:4052375[8] PMID:17050691[9]

complete

GO:0004174

electron-transferring-flavoprotein dehydrogenase activity

PMID:17712414[7]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P55931

F

PMID:4052375[8] PMID:17050691[9]

complete

GO:0009437

carnitine metabolic process

PMID:7473063[10]

IEP: Inferred from Expression Pattern

P

The fixABCX operon is adjacent to and regulated similarity to the cai operon, which is necessary for carnitine metabolism [11].

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

narH

PMID:16606699[12]

Experiment(s):EBI-1135423

Protein

dsbC

PMID:16606699[12]

Experiment(s):EBI-1135423

Protein

sdhA

PMID:16606699[12]

Experiment(s):EBI-1135423

Protein

ydjF

PMID:16606699[12]

Experiment(s):EBI-1135423

Protein

caiB

PMID:16606699[12]

Experiment(s):EBI-1135423

Protein

glnG

PMID:16606699[12]

Experiment(s):EBI-1135423

Protein

groL

PMID:16606699[12]

Experiment(s):EBI-1135423

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Notes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MSEDIFDAII VGAGLAGSVA ALVLAREGAQ VLVIERGNSA GAKNVTGGRL YAHSLEHIIP
GFADSAPVER LITHEKLAFM TEKSAMTMDY CNGDETSPSQ RSYSVLRSKF DAWLMEQAEE
AGAQLITGIR VDNLVQRDGK VVGVEADGDV IEAKTVILAD GVNSILAEKL GMAKRVKPTD
VAVGVKELIE LPKSVIEDRF QLQGNQGAAC LFAGSPTDGL MGGGFLYTNE NTLSLGLVCG
LHHLHDAKKS VPQMLEDFKQ HPAVAPLIAG GKLVEYSAHV VPEAGINMLP ELVGDGVLIA
GDAAGMCMNL GFTIRGMDLA IAAGEAAAKT VLSAMKSDDF SKQKLAEYRQ HLESGPLRDM
RMYQKLPAFL DNPRMFSGYP ELAVGVARDL FTIDGSAPEL MRKKILRHGK KVGFINLIKD
GMKGVTVL
Length

428

Mol. Wt

45.703 kDa

pI

5.9 (calculated)

Extinction coefficient

17,420 - 17,920 (calc based on 8 Y, 1 W, and 4 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure>fixC 562</beststructure>

Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc (EcoliWiki Page)

EcoCyc:EG11564-MONOMER

UniProt (EcoliWiki Page)

UniProt:P68644

PFAM (EcoliWiki Page)

PFAM:PF01266

RefSeq (EcoliWiki Page)

RefSeq:NP_414585

ModBase (EcoliWiki Page)

ModBase:P68644


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Notes

Links

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Name URL Comments
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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  6. ↑ 6.0 6.1 6.2 6.3 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  7. ↑ 7.0 7.1 7.2 Heinicke, S et al. (2007) The Princeton Protein Orthology Database (P-POD): a comparative genomics analysis tool for biologists. PLoS One 2 e766 PubMed
  8. ↑ 8.0 8.1 8.2 Beckmann, JD & Frerman, FE (1985) Electron-transfer flavoprotein-ubiquinone oxidoreductase from pig liver: purification and molecular, redox, and catalytic properties. Biochemistry 24 3913-21 PubMed
  9. ↑ 9.0 9.1 9.2 Zhang, J et al. (2006) Structure of electron transfer flavoprotein-ubiquinone oxidoreductase and electron transfer to the mitochondrial ubiquinone pool. Proc. Natl. Acad. Sci. U.S.A. 103 16212-7 PubMed
  10. ↑ Eichler, K et al. (1995) The fix Escherichia coli region contains four genes related to carnitine metabolism. J. Basic Microbiol. 35 217-27 PubMed
  11. ↑ Eichler, K et al. (1994) Molecular characterization of the cai operon necessary for carnitine metabolism in Escherichia coli. Mol. Microbiol. 13 775-86 PubMed
  12. ↑ 12.0 12.1 12.2 12.3 12.4 12.5 12.6 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed

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