umuD:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
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| Standard Name |
umuD |
|---|---|
| Gene Synonym(s) |
ECK1171, b1183, JW1172, uvm[1] |
| Product Desc. |
SOS mutagenesis; error-prone repair; processed to UmuD'; forms complex with UmuC[2][3]; Component of DNA polymerase V[3] DNA polymerase V subunit, capable of translesion synthesis; inducible mutagenesis; error-prone repair; UmuDC single-stranded binding protein with RecA-coated DNA; intrinsic AP lyase activity[4] |
| Product Synonyms(s) | |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity |
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Notes
LexA regulon. Autocleavage removes the first 24 amino acids to form UmuD', required for mutageneic translesion synthesis (TLS). UmuD and UmuD' are intrinsiclly disordered proteins (IDPs) that can nonetheless form stable dimers (Simon, 2008).[4]
References
- ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.