rpsL:Quickview
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RpsL is a ribosomal gene that encodes the highly conserved rps12 protein of the ribosomal accuracy center in the Escherichia coli. Numerous mutations in the rpsL gene generate resistance to, and in some instances dependence on, high levels of streptomycin. [1]
References
Mutations in regions 41-45 (except when lys42 is replaced with arg), 87-93 and 53 result in streptomycin resistance. A point mutation at 262 from A to G sustains protein synthesis in late stationary phase and increases the stability of the 70S complex in low magnesium concentrations.[1]