rppH:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
| Gene Name |
rppH [1] (synonyms: nudH, ECK2826, b2830, JW2798, ydgP, ygdP)[2] |
|---|---|
| Product(s) |
RppH product, RNA pyrophosphohydrolase [1], NudH product, nucleotide hydrolase product, B2830 product, YgdP product |
| Description |
RNA pyrophosphohydrolase (removes the 5'-pyrophosphate from mRNAs and initiates degradation by the 5'-end dependent pathway) [1]; putative invasion protein[3][4] |
| Knock-Out Phenotype |
Many mRNAs have an increased half-life. [1] |
| Regulation/Expression | |
| Regulation/Activity |
|
| edit table |
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Notes
Nudix hydrolase. RppH removes 5' triphosphate from primary transcripts, enhancing RNase E activity (Deana, 2008). Required for invasion of cultured mammalian cells by both E. coli K1 and S. typhimurium. NudH also hydrolyzes Ap5A and Ap4A. Ribosome-associated protein (Jiang, 2007).[5]
References
- ↑ 1.0 1.1 1.2 1.3 Deana, A et al. (2008) The bacterial enzyme RppH triggers messenger RNA degradation by 5' pyrophosphate removal. Nature 451 355-8 PubMed
- ↑ Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 3.0 3.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.