rhmA:Gene Product(s)
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| Nomenclature | Function | Interactions | Localization | Sequence | Structure | Resources | Accessions | Links | References | Suggestions |
Nomenclature
| Standard name |
YfaU product |
|---|---|
| Synonyms |
predicted 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase product[1], B2245 product[2][1], YfaU product[2][1] |
| Product description |
predicted aldolase[2][3] metal-dependent class II aldolase belonging to the pyruvate/enolpyruvate binding (�/R)8 barrel superfamily.[4], Genomic context suggested a 2-dehydro-3-deoxy sugar aldolase function rather than the 4-hydroxy-2-ketoheptane- 1,7-dioate aldolase function as annotated in the databases based on homology with the related HpcH. Functional assignment of YfaW as a L-rhamnonate dehydratase suggested 2-dehydro-3-deoxy-L-rhamnonate is the physiological substrate of YfaU, and enzyme kinetic measurements support this assignment. |
| EC number (for enzymes) |
|
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Notes
Function
Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
| Qualifier | GO ID | GO term name | Reference(s) | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003824 |
catalytic_activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc 12.5 [5] |
||||
| GO:0006725 |
aromatic_compound_metabolism |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc 12.5 [5] |
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| GO:0016829 |
lyase_activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc 12.5 [5] |
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| GO:0008152 |
metabolic process |
P |
Seeded from EcoCyc 11.1[3]. |
required fields missing | ||||
| GO:0016830 |
carbon-carbon_lyase_activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc 12.5 [5] |
| |||
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Interactions
| Partner Type | Partner | Notes |
|---|---|---|
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Notes
Localization
| Compartment | Description | Evidence | Notes |
|---|---|---|---|
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Notes
Structure and Physical Properties
Physical Properties
| Sequence |
MNALLSNPFK ERLRKGEVQI GLWLSSTTAY MAEIAATSGY DWLLIDGEHA PNTIQDLYHQ LQAVAPYASQ PVIRPVEGSK PLIKQVLDIG AQTLLIPMVD TAEQARQVVS ATRYPPYGER GVGASVARAA RWGRIENYMA QVNDSLCLLV QVESKTALDN LDEILDVEGI DGVFIGPADL SASLGYPDNA GHPEVQRIIE TSIRRIRAAG KAAGFLAVAP DMAQQCLAWG ANFVAVGVDT MLYSDALDQR LAMFKSGKNG PRIKGSY |
|---|---|
| Mol. Wt |
28.92 kDa (calc) [2] |
| pI | |
| Extinction coefficient |
36900 - 37150 (calc based on 10 Y, 4 W, and 2 C residues) |
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Domains/Motifs/Modification Sites
| Type | Residues | Description | Notes |
|---|---|---|---|
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Structure
| Structures | Models |
|---|---|
|
1.39 A structure of apo-YfaU and the Mg2+-pyruvate product complex [4] |
|
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Notes
Gene Product Resources
| Resource type | Source | Notes/Reference |
|---|---|---|
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Notes
Accessions in Other Databases
| Database | Accession | Notes |
|---|---|---|
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Notes
Links
| Name | URL | Comments |
|---|---|---|
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References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.0 1.1 1.2 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 Rea, D et al. (2008) Crystal structure and functional assignment of YfaU, a metal ion dependent class II aldolase from Escherichia coli K12. Biochemistry 47 9955-65 PubMed
- ↑ 5.0 5.1 5.2 5.3 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
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