htpX:Gene Product(s)

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Structure Resources Accessions Links References Suggestions

Nomenclature

Standard name

HtpX product

Synonyms

predicted endopeptidase product[1], B1829 product[2][1], HtpX product[2][1]

Product description

heat shock protein, integral membrane protein[2][3]

EC number (for enzymes)
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Notes

Function

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Gene Ontology

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0008270

zinc_ion_binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009481

F

Seeded from EcoCyc 12.5 [4]

GO:0008270

zinc_ion_binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0862

F

Seeded from EcoCyc 12.5 [4]

GO:0016020

membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001915

C

Seeded from EcoCyc 12.5 [4]

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0397

C

Seeded from EcoCyc 12.5 [4]

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

Seeded from EcoCyc 12.5 [4]

GO:0016021

integral_to_membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc 12.5 [4]

GO:0016787

hydrolase_activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0378

F

Seeded from EcoCyc 12.5 [4]

GO:0008237

metallopeptidase_activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0482

F

Seeded from EcoCyc 12.5 [4]

GO:0008270

zinc_ion_binding

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00188

F

Seeded from EcoCyc 12.5 [4]

GO:0004222

metalloendopeptidase_activity

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00188

F

Seeded from EcoCyc 12.5 [4]

GO:0004222

metalloendopeptidase_activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001915

F

Seeded from EcoCyc 12.5 [4]

GO:0004222

metalloendopeptidase_activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009481

F

Seeded from EcoCyc 12.5 [4]

GO:0006508

proteolysis

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001915

P

Seeded from EcoCyc 12.5 [4]

GO:0006950

response_to_stress

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0346

P

Seeded from EcoCyc 12.5 [4]

GO:0008233

peptidase_activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0645

F

Seeded from EcoCyc 12.5 [4]

GO:0009266

response to temperature stimulus

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0004222

metalloendopeptidase activity

PMID:16076848[5]

IDA: Inferred from Direct Assay

F

complete

GO:0046872

metal_ion_binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

Seeded from EcoCyc 12.5 [4]


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Interactions

Partner Type Partner Notes
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Notes

HtpX is ATP-independent and introduces endoproteolytic cuts in abnormal membrane proteins

Localization

Compartment Description Evidence Notes

plasma membrane

plasma membrane

C-terminus localized in the cytoplasm with 4 predicted transmembrane domains

Daley et al. (2005) [6]


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Notes

Structure and Physical Properties

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Physical Properties

Sequence

at EcoCyc 

MMRIALFLLT NLAVMVVFGL VLSLTGIQSS SVQGLMIMAL LFGFGGSFVS LLMSKWMALR
SVGGEVIEQP RNERERWLVN TVATQARQAG IAMPQVAIYH APDINAFATG ARRDASLVAV
STGLLQNMSP DEAEAVIAHE ISHIANGDMV TMTLIQGVVN TFVIFISRIL AQLAAGFMGG
NRDEGEESNG NPLIYFAVAT VLELVFGILA SIITMWFSRH REFHADAGSA KLVGREKMIA
ALQRLKTSYE PQEATSMMAL CINGKSKSLS ELFMTHPPLD KRIEALRTGE YLK
Mol. Wt

31.92 kDa (calc) [2]

pI
Extinction coefficient

22460 - 22585 (calc based on 4 Y, 3 W, and 1 C residues)

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Domains/Motifs/Modification Sites

Type Residues Description Notes
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Structure

Structure Type Organism Accession Residues covered Notes
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Notes

Gene Product Resources

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Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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Database Accession Notes

EcoCyc (EcoliWiki Page)

EcoCyc:EG10462-MONOMER

UniProt (EcoliWiki Page)

UniProt:P23894

PFAM (EcoliWiki Page)

PFAM:PF06509

RefSeq (EcoliWiki Page)

RefSeq:NP_416343

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Notes

Links

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Name URL Comments
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References

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  1. ↑ 1.0 1.1 1.2 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 4.15 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  5. ↑ Sakoh, M et al. (2005) Proteolytic activity of HtpX, a membrane-bound and stress-controlled protease from Escherichia coli. J. Biol. Chem. 280 33305-10 PubMed
  6. ↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed


Categories

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