cls:Gene Product(s): Difference between revisions
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{| | {| id="V46aa5f7651ffb" class=" tableEdit Product_nomenclature_table" | ||
|- | |- | ||
!align=left | !align=left |Standard name | ||
|| | || | ||
Cls | Cls | ||
|- | |- | ||
!align=left | !align=left |Synonyms | ||
|| | || | ||
cardiolipin synthase 1<ref name='LIB:Riley_2006'/>, B1249<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YciJ<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Nov<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Cls<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> | cardiolipin synthase 1<ref name='LIB:Riley_2006'/>, B1249<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YciJ<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Nov<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Cls<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> | ||
|- | |- | ||
!align=left | !align=left |Product description | ||
|| | || | ||
Cardiolipin synthase; mutants dihydroxybutylphosphonate resistant; novobiocin sensitivity<ref name='LIB:EcoGene'/> | Cardiolipin synthase; mutants dihydroxybutylphosphonate resistant; novobiocin sensitivity<ref name='LIB:EcoGene'/> | ||
|- | |- | ||
!align=left | !align=left |EC number (for enzymes) | ||
|| | || | ||
[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.8.- 2.7.8.-]<ref name='LIB:Riley_2006'/> | [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.8.- 2.7.8.-]<ref name='LIB:Riley_2006'/> | ||
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{| | {| id="T46aa5f775286b" class=" tableEdit GO_table_product dataTable" | ||
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!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status | !|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status | ||
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complete | complete | ||
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{| | {| id="O46aa5f85a6725" class=" tableEdit Product_interactions_table" | ||
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{| | {| id="D46aa5f865b450" class=" tableEdit Product_localization_table" | ||
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{| | {| id="C46aa5f87c8cd1" class=" tableEdit Product_phys_prop_table" | ||
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!align=left | !align=left |Sequence | ||
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[http://biocyc.org/ECOLI/sequence-aa?object=CARDIOLIPSYN-MONOMER at EcoCyc] | [http://biocyc.org/ECOLI/sequence-aa?object=CARDIOLIPSYN-MONOMER at EcoCyc] | ||
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FFSPLL</pre> | FFSPLL</pre> | ||
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!align=left | !align=left |Length | ||
|| | || | ||
486 | 486 | ||
|- | |- | ||
!align=left | !align=left |Mol. Wt | ||
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54.824 kDa | 54.824 kDa | ||
|- | |- | ||
!align=left | !align=left |pI | ||
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8.4 (calculated) | 8.4 (calculated) | ||
|- | |- | ||
!align=left | !align=left |Extinction coefficient | ||
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93,850 - 94,475 (calc based on 15 Y, 13 W, and 5 C residues) | 93,850 - 94,475 (calc based on 15 Y, 13 W, and 5 C residues) | ||
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!align=left | !align=left |Structures | ||
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<beststructure> | <beststructure> | ||
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</beststructure> | </beststructure> | ||
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!align=left | !align=left |Models | ||
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View models at: | View models at: | ||
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* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP) | * [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP) | ||
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{| | {| id="J46aa5f89259c0" class=" tableEdit Gene_accessions_table" | ||
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Revision as of 00:23, 9 January 2010
{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>
| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| Nomenclature | Function | Interactions | Localization | Sequence | Domains | Structure | Resources | Accessions | Links | References | Suggestions |
Nomenclature
See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
| Standard name |
Cls |
|---|---|
| Synonyms |
cardiolipin synthase 1[1], B1249[2][1], YciJ[2][1], Nov[2][1], Cls[2][1] |
| Product description |
Cardiolipin synthase; mutants dihydroxybutylphosphonate resistant; novobiocin sensitivity[3] |
| EC number (for enzymes) |
2.7.8.-[1] |
| edit table |
Notes
Function
Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
| Qualifier | GO ID | GO term name | Reference(s) | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0016780 |
phosphotransferase activity, for other substituted phosphate groups |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc [4] |
complete | |||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc [4] |
complete | |||
| GO:0016740 |
transferase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc [4] |
complete | |||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc 12.5 [5] |
complete | |||
| GO:0003824 |
catalytic activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc [4] |
complete | |||
| GO:0008152 |
metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc [4] |
complete | |||
| GO:0008808 |
cardiolipin synthase activity |
IMP: Inferred from Mutant Phenotype |
F |
Seeded from EcoCyc [4] |
complete | |||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
HAMAP:MF_00190 |
C |
Seeded from EcoCyc [4] |
complete | ||
| GO:0042493 |
response to drug |
P |
Seeded from EcoCyc 11.1[7]. |
required fields missing | ||||
| GO:0008808 |
cardiolipin synthase activity |
IMP: Inferred from Mutant Phenotype |
F |
complete | ||||
| edit table |
Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
| Partner Type | Partner | Notes | References | Evidence |
|---|---|---|---|---|
| edit table |
Notes
Required for synthesis of cardiolipin.
Localization
See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
| Compartment | Description | Evidence | Source | Notes |
|---|---|---|---|---|
|
plasma membrane |
From EcoCyc[7] |
| ||
| edit table |
Notes
Structure and Physical Properties
Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
| Sequence |
MTTVYTLVSW LAILGYWLLI AGVTLRILMK RRAVPSAMAW LLIIYILPLV GIIAYLAVGE LHLGKRRAER ARAMWPSTAK WLNDLKACKH IFAEENSSVA APLFKLCERR QGIAGVKGNQ LQLMTESDDV MQALIRDIQL ARHNIEMVFY IWQPGGMADQ VAESLMAAAR RGIHCRLMLD SAGSVAFFRS PWPELMRNAG IEVVEALKVN LMRVFLRRMD LRQHRKMIMI DNYIAYTGSM NMVDPRYFKQ DAGVGQWIDL MARMEGPIAT AMGIIYSCDW EIETGKRILP PPPDVNIMPF EQASGHTIHT IASGPGFPED LIHQALLTAA YSAREYLIMT TPYFVPSDDL LHAICTAAQR GVDVSIILPR KNDSMLVGWA SRAFFTELLA AGVKIYQFEG GLLHTKSVLV DGELSLVGTV NLDMRSLWLN FEITLAIDDK GFGADLAAVQ DDYISRSRLL DARLWLKRPL WQRVAERLFY FFSPLL |
|---|---|
| Length |
486 |
| Mol. Wt |
54.824 kDa |
| pI |
8.4 (calculated) |
| Extinction coefficient |
93,850 - 94,475 (calc based on 15 Y, 13 W, and 5 C residues) |
| edit table |
Domains/Motifs/Modification Sites
|
See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.
|
<motif_map/> |
|
Structure
|
Structure figures
Notes
Gene Product Resources
See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.
| Resource type | Source | Notes/Reference |
|---|---|---|
| edit table |
Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
| Database | Accession | Notes |
|---|---|---|
|
| ||
| edit table |
Notes
Links
| Name | URL | Comments |
|---|---|---|
| edit table |
References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
- ↑ EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 6.0 6.1 Pluschke, G et al. (1978) Function of phospholipids in Escherichia coli. Characterization of a mutant deficient in cardiolipin synthesis. J. Biol. Chem. 253 5048-55 PubMed
- ↑ 7.0 7.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
Categories
- GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups
- GO:0016021 ! integral component of membrane
- GO:0016740 ! transferase activity
- GO:0016020 ! membrane
- GO:0003824 ! catalytic activity
- GO:0008152 ! metabolic process
- GO:0008808 ! cardiolipin synthase activity
- GO:0005886 ! plasma membrane
- GO:0042493 ! response to drug
- TMHMM Prediction
- Proteins
- GO:0016021 ! integral to membrane
- GO:0008654 ! phospholipid biosynthetic process
- Location:plasma membrane
